Polymers in pharmaceutical taste masking applications

• Autorzy: Amelian A. , Winnicka K.

Identyfikatory

DOI

10.14314/polimery.2017.419

Warianty tytułu

PL

Polimery stosowane w technologiach farmaceutycznych do maskowania smaku substancji czynnych

• Języki publikacji: EN

Abstrakty

EN

Taste masking is an important factor in the development of dosage forms containing active pharmaceutical ingredients with unacceptable taste. Film coating has been found as the most effective and commonly used approach for taste masking. Depending on the taste masking technology, shell material should be selected from a wide variety of water soluble or insoluble polymers. The present article provides an overview of the commonly used polymers and ready-to-use polymer mixtures employed for taste masking.

PL

Maskowanie smaku jest ważnym czynnikiem w projektowaniu postaci leków zawierających substancje czynne o nieakceptowalnym smaku. Najskuteczniejszą i powszechnie stosowaną metodą maskowania smaku jest powlekanie opracowywanej postaci leku. Materiał otoczki stanowią rozpuszczalne lub nierozpuszczalne w wodzie polimery odpowiednio dobrane w zależności od metody maskowania smaku. W niniejszym artykule dokonano przeglądu polimerów oraz ich gotowych mieszanin, powszechnie używanych w celu zamaskowania smaku leku.

Słowa kluczowe

EN

taste masking; hypromellose; methyl cellulose; ethyl cellulose; methacrylate copolymers; ready-to-use polymer mixtures

PL

maskowanie smaku; hypromeloza; metyloceluloza; etyloceluloza; kopolimery metakrylanów; gotowe mieszaniny polimerów

• Wydawca: Sieć Badawcza Łukasiewicz – Instytut Chemii Przemysłowej
• Czasopismo: Polimery
• Rocznik: 2017
• Tom: T. 62, nr 6
• Strony: 419--427
• Opis fizyczny: Bibliogr. 64 poz., fot., rys.

Twórcy

autor

Amelian A.

• Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2C, 15-222 Białystok, Poland
• Department of Clinical Pharmacy, Medical University of Białystok, Mickiewicza 2A, 15-222 Białystok, Poland

autor

Winnicka K.

• Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2C, 15-222 Białystok, Poland

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Uwagi

PL

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).