Development of quantitative HPTLC–densitometry methods following a model approach for transfer of TLC screening methods for pharmaceutical products of cefixime, cefuroxime axetil, cephalexin⋅H2O, ciprofloxacin HCl, levofloxacin, and metronidazole

• Autorzy: Zhang D. , Armour E. , Sherma J.

Identyfikatory

DOI

10.1556/1326.2016.29409

• Języki publikacji: EN

Abstrakty

EN

Transfer of six thin-layer chromatography (TLC) Global Pharma Health Fund Minilab kit protocols for detecting fake or markedly substandard drugs in pharmaceutical products in the field to quantitative high-performance TLC (HPTLC)–densitometry methods was carried out using a model process published earlier. The developed and validated methods for tablets or capsules containing cefixime, cefuroxime axetil, cephalexin•H2O, ciprofloxacin HCl, levofloxacin, and metronidazole involved use of EMD Millipore Premium Purity silica gel 60 F254 plates, automated sample and standard solution application with a CAMAG Linomat 4, and automated densitometry with a CAMAG Scanner 3 for detection, identification, and quantification.

Słowa kluczowe

EN

Cefixime; cefuroxime axetil; cephalexin; ciprofloxacin; levofloxacin; metronidazole; thin-layer chromatography; TLC; model process for TLC to quantitative HPTLC–densitometry transfer; fake drug analysis

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2017
• Tom: Vol. 29, no. 4
• Strony: 484--486
• Opis fizyczny: Bibliogr. 13 poz., rys., tab.

Twórcy

autor

Zhang D.

• Department of Chemical and Biomolecular Engineering, Lafayette College, Easton, PA, USA

autor

Armour E.

• Department of Biology, Lafayette College, Easton, PA, USA

autor

Sherma J.

• Department of Chemistry, Lafayette College, Easton, PA, USA

Bibliografia

• [1] O'Sullivan, C. and Sherma, J. Acta Chromatogr. 2012 , 24 , 241 – 252.
• [2] Lianza, K. and Sherma, J. J. Liq. Chromatogr. Relat. Technol. 2013 , 36 , 2446 – 2462.
• [3] Popovic, N. and Sherma, J. Acta Chromatogr. 2014 , 26 , 615 – 623.
• [4] Nguyen, M. and Sherma, J. Trends Chromatogr. 2013 , 8 , 131 – 135.
• [5] Nguyen, M. and Sherma, J. J. Liq. Chromatogr. Relat. Technol. 2014 , 37 , 2956 – 2970.
• [6] Strock, J. ; Nguyen, M. ; and Sherma, J. J. Liq. Chromatogr. Relat. Technol. 2015 , 38 , 1126 – 1130.
• [7] Strock, J. ; Nguyen, M. ; and Sherma, J. , Acta Chromatogr. doi: 10.1556/1326.2016.28.3.6 , in press.
• [8] Zhang, D. ; Strock, J. ; and Sherma, J. J. Liq. Chromatogr. Relat. Technol. 2016 , 39 , 277 – 280.
• [9] Global Pharma Health Fund EV (GPHF) website, http://www.gphf.org , accessed on March 1, 2017.
• [10] Kenyon, A. S. and Layloff, T. P. http://www.pharmweb.net/pwmirror/library/tlc/tlcall.pdf , accessed on March 1, 2017.
• [11] Armour, E. and Sherma, J. Cefixime method, http://layloff.net/articles/Cefixime/modified/Minilab/Method.pdf , accessed on March 1, 2017.
• [12] Ferenczi-Fodor, K. ; Vegh Z. ; Nagy-Tuak, A. ; Renger, B. ; Zeller M. J. AOAC Int. 2001 , 84 , 1265 – 1276.
• [13] Kaale, E. ; Risha, P. ; Reich, E. ; and Layloff, T. P. J. AOAC Int. 2010 , 93 , 1836 – 1843 .

Uwagi

PL

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).