Antileukemic activity of the chemical constituents from Scutellaria barbata D. Don

• Autorzy: Ren Q. , Xia T. , Quan X. G. , Ding L. , Wang H. Y.

Identyfikatory

DOI

10.1556/1326.2017.29.3.10

• Języki publikacji: EN

Abstrakty

EN

Scutellaria barbata D. Don has been used as a traditional Chinese medicine for antitumor and anti-inflammatory. However, there were just a few investigations about S. barbata D. Don according to bioactivity-directed isolation and online identification for the chemical constituents. In this work, eight compounds were isolated from S. barbata D. Don. The three flavonoids indicated the cytotoxic activity against human leukemic Reh cell lines. In addition, the constituents of S. barbata D. Don were further characterized and identified by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS). The UHPLC- Q-TOF-MS method was in negative ion mode. HPLC separation was performed on a Tosoh TSK gel ODS-100V (4.6 × 150 mm, 3.0 μm) column by gradient elution using water containing 0.3% formic acid and acetonitrile as mobile phase at a flow rate of 0.8 mL min−1. A total of 18 compounds, including 4 phenolic acids and 14 flavonoids were tentatively characterized and identified by means of the retention time, accurate mass, and characteristic fragment ions.

Słowa kluczowe

EN

Scutellaria barbata D; UHPLC-Q-TOF-MS; antileukemic activity

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2017
• Tom: Vol. 29, no. 3
• Strony: 399--413
• Opis fizyczny: Bibliogr. 29 poz., rys.

Twórcy

autor

Ren Q.

• Department of Pharmacy, Jining Medical University, Rizhao, Shandong, China

autor

Xia T.

• Technology R&D Center, Guangdong Yifang Pharmaceutical Co., Ltd., Foshan 52824, China

autor

Quan X. G.

• Department of Pharmacy, Jining Medical University, Rizhao, Shandong, China

autor

Ding L.

• Department of Pharmacy, Jining Medical University, Rizhao, Shandong, China

autor

Wang H. Y.

• Department of Pharmacy, Jining Medical University, Rizhao, Shandong, China

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Uwagi

PL

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).