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Tytuł artykułu

Prospective Application of Response Surface Methodology for Predicting High-Energy Mixing Process Conditions towards Fine Powders Flow Improvement

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Języki publikacji
EN
Abstrakty
EN
Planetary ball mill was proposed as an intensive high-energy mixer to obtain flowability improvement of industrially exploited, cohesive and finely comminuted powders via dry coating. Response surface methodology (RSM) coupled with central composite rotatable design (CCRD) was applied as an effective method for the prediction of high-energy mixing conditions. The use of this procedure allows identifying relatively narrow ranges of high-energy mixing parameters (rotating speed of planetary ball mill and mixing time) and the amount of additives used (nanosilica and isopropyl alcohol) providing substantial improvement of the flowability of Aluminium hydroxide (Apyral) and Calcium carbonate powders. In order to find the optimal values of the process parameters, enabling to obtain the lowest values of flowability indices (angle of repose, compressibility index), the desirability function approach was applied. The obtained results may be a basis for developing a general routine allowing mixing parameters to be successfully predicted regarding some physical properties of powders only with no experiments needed.
Twórcy
  • Department of Chemical and Process Engineering, Rzeszow University of Technology, al. Powstancow Warszawy 6, 35-959 Rzeszow, Poland
  • Department of Chemical and Process Engineering, Rzeszow University of Technology, al. Powstancow Warszawy 6, 35-959 Rzeszow, Poland
Bibliografia
  • 1. Prescott J.K., Barnum R.A. On power flowability. Pharmaceutical Technology. 2000;24(10):60–84.
  • 2. Zhou Q., Qu L., Larson I., Stewart P.J., Morton D.A.V. Effect of mechanical dry particle coating on the improvement of powder flowability for lactose monohydrate: A model cohesive pharmaceutical powder. Powder Technology. 2011; 207(1–3): 414–21.
  • 3. Pfeffer R., Dave R.N., Wei D., Ramlakhan M. Synthesis of engineered particulates with tailored properties using dry particle coating. Powder Technology. 2001;117(1–2):40–67.
  • 4. Sonoda R., Horibe M., Oshima T., Iwasaki T., Wata- no S. Improvement of dissolution property of poorly water-soluble drug by novel dry coating method using planetary ball mill. Chemical and Pharmaceutical Bulletin (Tokyo). 2008;56(9):1243–7.
  • 5. Fokina E.L., Budim N.I., Kochnev V.G., Chernik G.G. Planetary mills of periodic and continuous action. Journal of Material Science. 2004;39(16/17):5217–21.
  • 6. Perthué A., Bussière P.-O., Baba M., Larche J.-F., Therias S., Karasu F., Croutxé-Barghorn C. Impact of particle size in PE/ATH composites: The rela- tionship between the interphase and water uptake. Progress in Organic Coatings. 2018;114:145–53.
  • 7. Leś K., Kowalski K., Opaliński I. Optimisation of process parameters in high energy mixing as a method of cohesive powder flowability improvement. Chemical and Process Engineering – Inżynieria Chemiczna i Procesowa. 2015;36(4):449–60.
  • 8. Evonik Resource Efficiency, Gmbh. AEROSIL ®200 Hydrophilic fumed silica. 2018.
  • 9. Jiao C.-M., Chen X.-L. Influence of fumed silica on the flame-retardant properties of ethylene vinyl acetate/aluminum hydroxide composites. Journal of Applied Polymer Science. 2011;120(3):1285–9.
  • 10. Gabbitas B., Cao P., Raynova S., Zhang D. Microstructural evolution during mechanical milling of Ti/Al powder mixture and production of intermetallic TiAl cathode target. Journal of Material Science. 2012;47(3):1234–43.
  • 11. Jallo L.J., Ghoroi C., Gurumurthy L., Patel U., Davé R.N. Improvement of flow and bulk density of pharmaceutical powders using surface modification. International Journal of Pharmaceutics. 2012;423(2):213–25.
  • 12. Aslan N. Application of response surface methodology and central composite rotatable design for modeling and optimization of a multigravity separator for chromite concentration. Powder Technology. 2008;185(1):80–6.
  • 13. StatSoft I. Big Data, Data Mining, Predictive Analytics, Statistics, StatSoft Electronic Textbook. Electronic Statistics Textbook. 2013. http://www. statsoft.com/textbook (accessed May 23, 2019)
Uwagi
Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-d5098518-f17d-4d6c-ad85-63141cc9b3a2
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