Effect of the type of amino acid on the biodegradation of ibuprofen derivatives

• Autorzy: Ossowicz-Rupniewska Paula Elżbieta , Kucharska Edyta , Klebeko Joanna , Kopciuch Ewelina , Bilska Karolina , Janus Ewa

Identyfikatory

DOI

10.24425/aep.2023.148685

• Języki publikacji: EN

Abstrakty

EN

Water pollution caused by anthropogenic activity is a huge environmental problem. Huge amounts of consumed medicinal substances cause them to get into the environment. Non-steroidal anti-inflammatory drugs, including ibuprofen, are one of the most popular drugs in the world. This article presents the biodegradation of ibuprofen and isopropyl ester salts of various amino acids. Twelve ibuprofen isopropyl esters of L-amino acids were used in the research. The obtained derivatives may be a safer and more effective alternative to ibuprofen. Biodegradation tests were carried out using activated sludge. Sewage sludge was obtained from the local sewage treatment plant in Szczecin "Pomorzany". Ibuprofen derivatives, ibuprofenates of isopropyl amino acid esters, were used for the tests. It was checked how the type of structural modification of ibuprofen affects the biodegradation of the drug used. In this publication, it was verified how the type of amino acid affects biodegradation. Our evaluation of the biodegradation of ibuprofen derivatives by bacterial cultures revealed that six compounds are attractive carbon and energy sources for the active material utilized. These compounds were readily biodegradable within 28 days. There were no straightforward relationships between the structure, properties, and biodegradability of the obtained derivatives.

Słowa kluczowe

EN

biodegradability; ibuprofen; amino acids isopropyl ester ibuprofenates; metabolites; nonsteroidal antiinflammatory drug

• Wydawca: Institute of Environmental Engineering, Polish Academy of Sciences
• Czasopismo: Archives of Environmental Protection
• Rocznik: 2023
• Tom: Vol. 49, no 4
• Strony: 46--69
• Opis fizyczny: Bibliogr. 43 poz., rys., tab., wykr.

Twórcy

autor

Ossowicz-Rupniewska Paula Elżbieta

• Department of Chemical Organic Technology and Polymeric Materials, West Pomeranian University of Technology in Szczecin, Poland

• https://orcid.org/0000-0002-2362-1809+

autor

Kucharska Edyta

• Department of Chemical Organic Technology and Polymeric Materials, West Pomeranian University of Technology in Szczecin, Poland

• https://orcid.org/0000-0002-6380-5848

autor

Klebeko Joanna

• Department of Chemical Organic Technology and Polymeric Materials, West Pomeranian University of Technology in Szczecin, Poland

• https://orcid.org/0000-0002-3176-5511+

autor

Kopciuch Ewelina

• Department of Chemical Organic Technology and Polymeric Materials, West Pomeranian University of Technology in Szczecin, Poland

• https://orcid.org/0000-0002-2829-8158

autor

Bilska Karolina

• Department of Chemical Organic Technology and Polymeric Materials, West Pomeranian University of Technology in Szczecin, Poland

autor

Janus Ewa

• Department of Chemical Organic Technology and Polymeric Materials, West Pomeranian University of Technology in Szczecin, Poland

• https://orcid.org/0000-0002-7396-9424+

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