αBSM failed as a carrier of rhBMP-2 to enhance bone consolidation in a sheep model of distraction osteogenesis

• Autorzy: Floerkemeier T. , Thorey F. , Wellmann M. , Hurschler C. , Budde S. , Windhagen H.

Identyfikatory

DOI

10.5277/ABB-00946-2017-02

• Języki publikacji: EN

Abstrakty

EN

One of the problems associated with callus distraction is a long time period needed for consolidation of the newly formed bone. The goal of this study was to determine whether percutaneous injections of rhBMP 2 in BSM would enhance bone consolidation. Methods: A unilateral tibial osteotomy combined with external stabilization was performed in 20 adult sheep. After a latency of four days, distraction was conducted for 20 days. Sheep were divided into three groups: group 1 received rhBMP-2/αBSM injections at day 23 and 30, group 2 buffer/BSM injections at day 23 and 30 and group 3 did not receive any injection. The radiographs and in-vivo torsional stiffness measurements were obtained weekly during the following 50 days. Post-mortem bone densitometry (DXA) and mechanical testing were performed. Results: In-vivo stiffness assessments, DXA values and the maximum torsional moment of the sheep tibia treated with two rhBMP-2 injections were not significantly greater than those of both control groups. Conclusions: Presented application of rhBMP-2 in BSM failed to enhance bone consolidation in distraction osteogenesis.

Słowa kluczowe

EN

rhBMP-2; growth factors; αBSM; bone consolidation; biomechanical testing; DXA

PL

czynniki wzrostu; kości; test biomechaniczny; DXA

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2017
• Tom: Vol. 19, no. 4
• Strony: 55--62
• Opis fizyczny: Bibliogr. 30 poz., wykr.

Twórcy

autor

Floerkemeier T.

• Department of Orthopaedic Surgery, Hannover Medical School, Germany

autor

Thorey F.

• ATOS clinic Heidelberg, Germany

autor

Wellmann M.

• Department of Orthopaedic Surgery, Hannover Medical School, Germany

autor

Hurschler C.

• Laboratory of Biomechanics, Hannover Medical School, Germany

autor

Budde S.

• Department of Orthopaedic Surgery, Hannover Medical School, Germany

autor

Windhagen H.

• Department of Orthopaedic Surgery, Hannover Medical School, Germany

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Uwagi

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).