Szczęście i ciężka praca w opracowywaniu leków

• Autorzy: Koroniak Łukasz

Warianty tytułu

EN

Luck and hard work in drug discovery

• Języki publikacji: PL

Abstrakty

EN

Luck is one of the critical factors determining outcome of many activities we are involved in. In chemistry, and specifically in drug discovery a strike of luck can determine a successful study outcome leading to an approval of potentially blockbuster drug consequently offering a new treatment option for patients in need. On the other hand, lack of luck can often result in termination of activities, wasted resources and years of studies and often have negative impact on a fate of companies and its employees. In a similar fashion, hard work is critical for one’s success. It is not meant in a literal fashion, but rather from the perspective of “going the extra mile” in scientific research and development. It is meant as a proper approach to analysis of study outcome and understanding the reasons “why”, rather than accepting simply yes/no outcomes. Below article discusses two instances where certain level of luck and extra effort invested in understanding of widely available results led to development of two novel therapeutics in oncology field. Described stories deal with development of Abraxane, novel formulation of paclitaxel commercialized by Abraxis Bioscience as well as enzalutamid (Xtandi®) discovered at UCLA and developed and commercialized by Medivation and Astellas Pharma.

Słowa kluczowe

PL

chemoterapia; paclitaxel; enzalutamide; receptor androgenowy; rak prostaty; opracowywanie leków

EN

chemotherapy; paclitaxel; enzalutamide; androgen receptor; prostate cancer; drug discovery

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2020
• Tom: [Z] 74, 3-4
• Strony: 135--144
• Opis fizyczny: Bibliogr. 22 poz., rys., schem.

Twórcy

autor

Koroniak Łukasz

• DSMBiomedical B. V., Koestraat 1, 6167 RA Geleen, Netherlands

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).