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Although clear evidence of significant differences in bone properties have been extensively studied, results vary under the ranges usually used for sterilization purposes (25-35 kGy). Hence, the aim of this work was the study of the mechanical properties and microdamage development of human bones used as allografts following gamma-ray exposure, followed by an extensive statistical analysis of microdamage effects in fatigue behaviour. Methods: Specimens of the cortical region of human femurs were exposed to 15-25 kGy and 26-30 kGy radiation levels, then they were subjected to compression fatigue tests until fracture. The fatigue life was determined in relation to the radiation level, and the evolution of microdamage was assessed through fluorescence microscopy in order to calculate characteristic lengths of microcracks. Results: Significant differences in fatigue life were detected (p < 0.05) between non-radiated (control) and radiated specimens, resulting in a drastic 89.2% fatigue life reduction of the 15-25 kGy group, and 95.3% in the 26-30 kGy group in comparison to the control. Microdamage analysis showed a considerable increase in microcrack lengths when bone was exposed to gamma radiation, which may indicate that bones used as allografts could fracture at some point when subjected to in vivo loading conditions. Conclusions: The results of our research indicate that, even if a range of 15-25 kGy is suggested to sterilize bone allografts, such practice needs to be reconsidered. In addition, with use of Weibull distribution, this work describes the conditions in which microcracks grow towards the fracture of bones in relation to the decrease in their mechanical properties.
Czasopismo
Rocznik
Tom
Strony
43--53
Opis fizyczny
Bibliogr. 25 poz., rys.
Twórcy
autor
- Facultad de Ingeniería, Universidad Nacional Autónoma de México. Polo Universitario de Tecnología Avanzada (PUNTA/UNAM), Monterrey, México
- Facultad de Ingeniería Mecánica y Eléctrica, Universidad Autónoma de Nuevo León, México
- Facultad de Ingeniería Mecánica y Eléctrica, Universidad Autónoma de Nuevo León, México
autor
- Facultad de Medicina, Universidad Autónoma de Nuevo León, México
autor
- Escuela Superior de Ingeniería Mecánica y Eléctrica (ESIME), Instituto Politécnico Nacional, México
autor
- Centro de Investigación y de Estudios Avanzados (Cinvestav), Monterrey, México
Bibliografia
- [1] Akkus, O., 2001, Fracture resistance of gamma radiation sterilized cortical bone allografts, Journal of Orthopaedic Research, 19, 927-934.
- [2] Akkus, O., and R. M. Ryan M. Belaney, Sterilization by gamma radiation impairs the tensile fatigue life of cortical bone by two orders of magnitude, Journal of Orthopaedic Research, 2005, 23, 1054-1058.
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- [7] Currey, J. D., J. Foreman, I. Laketic, J. Mitchell, D. E. Pegg, and G. C. Reilly, Effects of ionizing radiation on the mechanical properties of human bone, Journal of Orthopaedic Research, 1997, 15, 111-7.
- [8] Emes, Y., M. Ipekoğlu, H. Haznedaroğlu, H. Işsever, S. Yalçin, and S. Altintaş, The effects of freeze drying and solvent dehydration on the bending strength and calcium content of corticalbone, Acta Orthop Traumatol Turc, 2011, 45, 365-9.
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- [12] Hernigou, P., G. Marinello, and D. Dormont, Influence of irradiation on the risk of HIV virus transmission by bone allograft, Rev Chir Orthop Reparatrice Appar Mot, 1998, 84, 493-500.
- [13] Islam, A., K. Chapin, E. Moore, J. Ford, C. Rimnac, and O. Akkus, Gamma Radiation Sterilization Reduces the High-cycle Fatigue Life of Allograft Bone, Clin Orthop Relat Res, 2016, 4, 827-35.
- [14] Kaminski, A., A. Jastrzebska, E. Grazka, J. Marowska, G. Gut, A. Wojciechowski, and I. Uhrynowska-Tyszkiewicz, Effect of gamma irradiation on mechanical properties of human cortical bone: influence of different processing methods, Cell Tissue Bank, 2012, 13, 363-374.
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- [16] Mankin, H. J., F. J. Hornicek, and K. A. Raskin, Infection in massive bone allografts, Clin Orthop Relat Res, 2005, 432, 210-6.
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- [18] Mikhael, M. M., P. M. Huddleston, M. E. Zobitz, Q. Chen, K. D. Zhao, and K. N. An, Mechanical strength of bone allografts subjected to chemical sterilization and other terminal processing methods, J Biomech, 2008, 41, 2816-20.
- [19] Mitchell, E. J., A. M. Stawarz, R. Kayacan, and C. M. Rimnac, The effect of gamma radiation sterilization on the fatigue crack propagation resistance of human cortical bone, J Bone Joint Surg Am., 2004, 86-A, 2648-57.
- [20] Mroz, T. E., E. L. Lin, M. C. Summit, J. R. Bianchi, J. E. J. Keesling, M. Roberts, C. T. J. Vangsness, and J. C. Wang, Biomechanical analysis of allograft bone treated with a novel tissue sterilization process, Spine J., 2006, 6, 34-9.
- [21] O' Brien, F. J., D. Taylor, and T. C. Lee, Microcrack accumulation at different intervals during fatigue testing of compact bone, Journal of Biomechanics, 2003, 36, 973-980.
- [22] O' Brien, F. J., D. Taylor, and T. C. Lee, The effect of bone microstructure on the initiation and growth of microcracks, Journal of Orthopaedic Research, 2005, 23, 475-480.
- [23] Presbitero, G., F. J. O'Brien, T. C. Lee, and D. Taylor, Distribution of microcrack lengths in bone in vivo and in vitro, J Theor Biol, 2012, 7, 164-71.
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Uwagi
Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-d2045cf1-713d-4256-8e91-1bdaf1cb0234