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Aerosol Generation and Identification for Model Studies of Particle–Lung Interactions

Treść / Zawartość
Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
This article discusses the idea and set-up of a laboratory system for generating reproducible concentrated occupational aerosols containing metal compounds. Dust representatives for 2 metal-machining workstations (an electric grinder and an electric disc cutter) were released from a fluidized-bed generator, and then sampled and compared in respect to concentration, particle size distribution, particle morphology and the content of metal elements (Fe, Al, Cu, Mn, Cr, Ni, Pb, Zn, Mg). The results indicate the presence of a significant number of irregularly-shaped respirable particles. Those particles contained mainly Fe and Al, and their composition was shown to depend on particle size. The proposed system of aerosol generation and collection can be used in studies of interactions between airborne particles and a model lung surfactant.
Rocznik
Strony
41--48
Opis fizyczny
Bibliogr. 19 poz., rys., tab., wykr.
Twórcy
autor
  • Department of Chemical and Aerosol Hazards, Central Institute for Labour Protection – National Research Institute (CIOP-PIB), Poland
  • Faculty of Chemical and Process Engineering, Warsaw University of Technology, Warsaw, Poland
Bibliografia
  • 1.Gawęda E, Kondej D. Occupational risk assessment to metals in manufacturing processes of metal accessories [abstract]. In: XVIII Mendeleev Congress on General and Applied Chemistry. Moscow, Russia: Granitsa; 2007. vol. 3, p. 47.
  • 2.Statistical Yearbook of the Republic of Poland 2007. Warszawa, Poland: Zakład Wydawnictw Statystycznych; 2007. p. 238–45. In Polish.
  • 3.Palmer KT, Ayres JG, Mann J, Burge PS, Coggon D. Exposure to metal fume and infectious pneumonia. Am J Epidemiol. 2003;157: 227–33.
  • 4.Ruediger HW. Hard metal particles and lung disease: coincidence or causality? Respiration. 2000;67:137–8.
  • 5.Warheit DB, Brock WJ, Lee KP, Webb TR, Reed KL. Comparative pulmonary toxicity inhalation and instillation studies with different TiO2 particle formulations: impact of surface treatments on particle toxicity. Toxicol Sci. 2005;88:514–24.
  • 6.Nordberg FG, Fowler BA, Nordberg M, Friberg LT, editors. Handbook on the toxicology of metals. 3rd ed. Burlington, MA, USA: Academic Press; 2007.
  • 7.Rom WN, editor. Environmental & occupational medicine. 3rd ed. Philadelphia, PA, USA: Lippincott-Raven; 1998.
  • 8.Saxena S. Lung surfactant. The indispensable component of respiratory mechanics. Resonance. 2005;10(8);91–6.
  • 9.Enhorning G. Surfactant in airway disease. Chest. 2008;13:975–80.
  • 10.Wright JR. Pulmonary surfactant: a front line of lung host defense. J Clin Invest. 2003;111:1453–5.
  • 11.Sosnowski TR. Dynamic surface tension as an indicator of lung function in health and disease. Biocyb Biomed Eng. 2003;23:89–98.
  • 12.Kondej D, Sosnowski TR. Laboratory system for metal dusts generation [abstract T09A029P] [pendrive]. In: European Aerosol Conference, Thessaloniki; 2008.
  • 13.Notter RH, Taubold R, Mavis RD. Hysteresis in saturated phospholipid films and its potential relevance for lung surfactant functions in vivo. Exp Lung Res. 1982; 3:109–27.
  • 14.Sosnowski TR, Podgórski A. Assessment of the pulmonary toxicity of inhaled gases and particles with physicochemical methods. International Journal of Occupational Safety and Ergonomics (JOSE). 1999;5:433–49.
  • 15.Enhorning G. Pulsating bubble technique for evaluating pulmonary surfactant. J Appl Physiol. 1977;43:198–203.
  • 16.Sosnowski TR, Gradoń L, Podgórski A. Influence of insoluble aerosol deposits on the surface activity of the pulmonary surfactant: a possible mechanism of alveolar clearance retardation? Aerosol Sci Techn. 2000;32:52–60.
  • 17.Sosnowski TR, Gradoń L, Iskandar F, Okuyama, K. Interaction of deposited aerosol particles with the alveolar liquid layer. In: Gradoń L, Marijnissen J, editors. Optimization of aerosol drug delivery. Dordrecht, The Netherlands: Kluwer Academic; 2008. p. 205–16.
  • 18.Jankowska E, Kondej D. Mass and number dust concentrations at industrial and office workplaces. J Aerosol Sci. 2003;1:393–4.
  • 19.Bakhsi MS, Zhao L, Smith R, Possmayer F, Petersen NO. Metal nanoparticle pollutants interfere with pulmonary surfactant function in vitro. Biophys J. 2008;94:855–68.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-d0f92bd4-5d35-4cc5-90de-2c300aefb008
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