Evaluation of the biocompatibility of a hydroxyapatite-CaTiO₃ coating in vivo

• Autorzy: Wu S. , Tu B. , Lin J. , Wang Z. , Wang X. , Shen M. , Hu R.

Identyfikatory

DOI

10.1016/j.bbe.2015.05.001

• Języki publikacji: EN

Abstrakty

EN

Objective: This study was designed to evaluate the biocompatibility and osteointegrative activity of hydroxyapatite (HA)-CaTiO₃, titanium substrate, traditional HA coating and CaTiO₃ coating via an animal experiment. Method: Four types of screws (type 1: coated with HA; type 2: coated with CaTiO₃; type 3: coated with HA-CaTiO₃; type 4: untreated titanium screws) were implanted into femur bone of 48 New Zealand rabbits. Histological and mechanical investigations were employed at the end of 2, 4, 8 and 12 weeks to evaluate the material osteointegration. Results: (1) All of the experimental rabbits were healthy during the experiment process. (2) Histological investigation showed fully regenerated and well integrated bone tissue surrounding the screws coated with HA, HA-CaTiO₃ and CaTiO₃. (3) Mechanical investigation showed that the bonding strength of HA-CaTiO₃ coating was significantly higher than that of CaTiO₃ coating or titanium materials without coating, but was lower than those coated with HA. Conclusion: HA-CaTiO₃ coating possesses similar admirable biocompatibility and osteointegration activity with HA coating, indicating a promising coating material for implants in orthopedics.

Słowa kluczowe

EN

biological evaluation; biomechanics testing; coatings; HA-CaTiO3; hydroxyapatite

PL

ocena biologiczna; badanie biomechaniczne; powłoki; HA-CaTiO3; hydroksyapatyt

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2015
• Tom: Vol. 35, no. 4
• Strony: 296--303
• Opis fizyczny: Bibliogr. 25 poz., rys., tab.

Twórcy

autor

Wu S.

• The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

autor

Tu B.

• The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

autor

Lin J.

• The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

autor

Wang Z.

• The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

autor

Wang X.

• The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

autor

Shen M.

• The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

autor

Hu R.

• The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

Bibliografia

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