Multiple emulsions as carriers for the topical delivery of anti-inflammatory drugs

• Autorzy: Markowska-Radomska Agnieszka , Skowronski Patryk , Dluska Ewa , Kosicki Konrad

Identyfikatory

DOI

10.24425/cpe.2023.144701

• Konferencja: 24th Polish Conference of Chemical and Process Engineering, 13-16 June 2023, Szczecin, Poland. Guest editor: Prof. Rafał Rakoczy and 8th European Process Intensification Conference, 31.05–2.06.2023, Warsaw, Poland
• Języki publikacji: EN

Abstrakty

EN

Radiation therapy can be adopted for many cancers, and it can damage healthy tissues and often induces skin lesions (pain/skin irritation/itchiness/dryness/swelling/redness). Many factors influence the adverse effects of radiotherapy, such as radiation dosage, dose frequency and fractioning, the area of skin exposed to radiation and treatment length. In this paper, multiple emulsions with a nonsteroidal anti-inflammatory drug-NSAID (diclofenac) were developed and evaluated for effective topical treatment of skin lesions following anti-cancer therapy. Multiple emulsions with different drop sizes were prepared in a Couette-Taylor flow contactor. High encapsulation efficiency (> 90%) of diclofenac and high volume packing fraction of the internal droplets (0.54–0.96) were obtained. In addition, due to the presence of a polymer with adhesive properties – sodium carboxymethylcellulose, high emulsion stability (> 60 days) was achieved. The emulsions displayed properties of shear-thinning fluids. The release study of diclofenac from a complex emulsion structure confirmed the possibility of modifying the release rates. The effectiveness of emulsion formulations was evaluated based on the viability tests of the fibroblast cell line irradiated with UV dose (15 J/m2) and then treated with the emulsion with diclofenac. The results showed that the multiple emulsion-based formulations might be appropriate carriers for the topical delivery of NSAID drugs.

Słowa kluczowe

EN

multiple emulsion; skin lesions; nonsteroidal anti-inflammatory drugs; drug release; controlled-prolonged delivery

PL

emulsja wielokrotna; zmiany skórne; niesteroidowe leki przeciwzapalne; uwalnianie leku; dostarczanie

• Wydawca: Komitet Inżynierii Chemicznej i Procesowej Polskiej Akademii Nauk
• Czasopismo: Chemical and Process Engineering : New Frontiers
• Rocznik: 2023
• Tom: Vol. 44, nr 3
• Strony: art. no. e15
• Opis fizyczny: Bibliogr. 25 poz., rys., tab., wykr.

Twórcy

autor

Markowska-Radomska Agnieszka

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warsaw, Poland

• https://orcid.org/0000-0001-8951-2480

autor

Skowronski Patryk

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warsaw, Poland

• https://orcid.org/0000-0002-3510-5588

autor

Dluska Ewa

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warsaw, Poland

• https://orcid.org/0000-0001-8833-2744

autor

Kosicki Konrad

• University of Warsaw, Faculty of Biology, Institute of Genetics and Biotechnology, Adolfa Pawińskiego 5A, 02-106 Warsaw, Poland

• https://orcid.org/0000-0001-6369-8299

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr POPUL/SP/0154/2024/02 w ramach programu "Społeczna odpowiedzialność nauki II" - moduł: Popularyzacja nauki (2025)