Comparison of the structure of Aβ(1-40) amyloid with the one in complex with polyphenol ε-viniferin glucoside (EVG)

• Autorzy: Dułak D. , Banach M. , Wiśniowski Z. , Konieczny L. , Roterman I.

Identyfikatory

DOI

10.1515/bams-2018-0008

• Języki publikacji: EN

Abstrakty

EN

The analysis of amyloid structures is much easier recently due to the availability of the solid-state nuclear magnetic resonance technique, which allows the determination of the 3D structure of amyloid forms. The amyloidogenic polypeptide Aβ(1-40) (PDB ID 2M9R, 2M9S) in its soluble form is the object of analysis in this paper. The solubility of this polypeptide is reached due to the presence of a complexed ligand: polyphenol ε-viniferin glucoside. Two forms of complexes available in the PDB were taken for analysis with respect to the presence of a hydrophobic core in the 3D structure of these complexes. The idealized hydrophobic core structure assumed to be accordant with the 3D Gauss function distribution was taken as the pattern. The aim of this analysis is the possible further comparison to the structures of the hydrophobic core present in amyloids. It is shown that the discordant (versus the 3D Gauss function) fragments present in amyloids appear accordant in the discussed complexes.

Słowa kluczowe

EN

Aβ(amyloid); amyloid; solubility

• Wydawca: Uniwersytet Jagielloński - Collegium Medicum ; Index Copernicus Sp. z o.o.
• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2018
• Tom: Vol. 14, no. 2
• Strony: art. no. 20180008
• Opis fizyczny: Bibliogr. 21 poz., rys., tab.

Twórcy

autor

Dułak D.

• Jagiellonian University Medical College, 31-034 Krakow, Poland

autor

Banach M.

• Jagiellonian University Medical College, 31-034 Krakow, Poland

autor

Wiśniowski Z.

• Jagiellonian University Medical College, 31-034 Krakow, Poland

autor

Konieczny L.

• Jagiellonian University Medical College, 31-034 Krakow, Poland

autor

Roterman I.

• Jagiellonian University Medical College, Łazarza 16, 31-034 Krakow, Poland

Bibliografia

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Uwagi

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2019).