Effects of processing parameters on the properties of amphiphilic block copolymer micelles prepared by supercritical carbon dioxide evaporation method

• Autorzy: Jiao Z. , Wang Z. , Wang X. , Fan W.

Identyfikatory

DOI

10.2478/pjct-2018-0012

• Języki publikacji: EN

Abstrakty

EN

The operation parameters for the supercritical carbon dioxide (ScCO₂ ) evaporation method greatly affect the properties of the prepared drug-loaded micelles. In this study, the effects of those key parameters on the drug-loading content (LC) and drug entrapment efficiency (EE) are discussed. It is observed that EE and LC of the micelles are slightly increased with the enhancing temperature and the copolymer molecular ratio of hydrophilic/hydrophobic segment, while decreased with the enhancing ScCO₂  evaporation rate. The pressure and volume ratio of ScCO₂  to H₂ O are observed the optimum condition. In addition, the verification experiment is carried out under the obtained optimizing parameters. The prepared micelles exhibit relatively regular spherical shape and narrow size distribution with the EE and LC value of 70.7% and 14.1%, respectively.

Słowa kluczowe

EN

supercritical carbon dioxide; amphiphilic block copolymer; drug-loaded micelles; processing parameters; optimization

• Wydawca: West Pomeranian University of Technology. Publishing House
• Czasopismo: Polish Journal of Chemical Technology
• Rocznik: 2018
• Tom: Vol. 20, nr 1
• Strony: 81--86
• Opis fizyczny: Bibliogr. 32 poz., rys., tab.

Twórcy

autor

Jiao Z.

• Southeast University, School of Chemistry and Chemical Engineering, Nanjing 211189, China
• Joint Research Institute of Southeast University and Monash University, Center for Nanobiotechnology, Suzhou 215123, China

autor

Wang Z.

• Southeast University, School of Chemistry and Chemical Engineering, Nanjing 211189, China

autor

Wang X.

• Southeast University, School of Chemistry and Chemical Engineering, Nanjing 211189, China

autor

Fan W.

• Southeast University, School of Chemistry and Chemical Engineering, Nanjing 211189, China

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Uwagi

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).