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Insulin resistance: Risk factors, diagnostic approaches and mathematical models for clinical practice, epidemiological studies, and beyond

Autorzy
Krzymien Janusz , Ladyzynski Piotr
Wybrane pełne teksty z tego czasopisma
Identyfikatory
DOI
10.1016/j.bbe.2023.12.004
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Insulin resistance (IR) is a multifactorial metabolic disorder associated with the development of cardiometabolic syndrome, cardiovascular diseases and obesity. Factors such as inflammation, hyperinsulinemia, hyperglucagonemia, mitochondrial dysfunction, glucotoxicity and lipotoxicity contribute to the development of IR. Despite being extensively studied for over 60 years, assessing the incidence of IR, developing effective prevention strategies, and implementing appropriate therapeutic approaches remain challenging. This review explores the multifaceted nature of IR, including its association with various conditions such as obesity, primary hypertension, dyslipidemia, obstructive sleep apnea, Alzheimer’s disease, non-alcoholic fatty liver disease, polycystic ovary syndrome, chronic kidney disease and cancer. Additionally, we discuss the complexity of diagnosing and quantifying IR, emphasizing the lack of absolute, common criteria for classification. We delve into the use of mathematical models in clinical and epidemiological studies, focusing on the choice between insulin, triglycerides, or waist-to-hip ratio as IR determinants. Furthermore, we highlight the importance of reliable input data and caution in interpreting results when utilizing mathematical models for IR assessment. This narrative review aims to provide insights into the challenges and considerations involved in conducting IR diagnostics, with implications for clinical practice, epidemiological research, and future advancements in this field.
Słowa kluczowe
EN
PL
Wydawca
Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences
Elsevier
Czasopismo
Biocybernetics and Biomedical Engineering
Rocznik
2024
Tom
Vol. 44, no. 1
Strony
55--67
Opis fizyczny
Bibliogr. 161 poz., rys., tab.
Twórcy
autor
Krzymien Janusz
  • Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland
autor
Ladyzynski Piotr
pladyzynski@ibib.waw.pl
  • Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, 4 Trojdena Street, 02-109 Warsaw, Poland
Bibliografia
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