N, N –Dimetyloanilina. Dokumentacja proponowanych wartości dopuszczalnych poziomów narażenia zawodowego

• Autorzy: Starek A.

Warianty tytułu

EN

N,N-Dimethylaniline

• Języki publikacji: PL

Abstrakty

PL

N,N-Dimetyloanilina (DMA) jest stosowana jako rozpuszczalnik organiczny i półprodukt do syntezy organicznej. Narażenie na ten związek w przemyśle jest słabo udokumentowane. Zarówno po jednorazowym jak i powtarzanym podawaniu DMA, tak u ludzi jak i zwierząt, dochodzi do zmian hematotoksycznych pod postacią methemoglobinemii i objawów sinicy, powiększenia śledziony i pozaszpikowej hematopoezy. Związek ten działa klastogennie, natomiast nie wykazano jego działania rakotwórczego, embriotoksycznego, fetotoksycznego i teratogennego. Wartość NDS obliczono na podstawie wyników doświadczeń na szczurach, którym DMA podawano dożołądkowo i obserwowano działanie hematotoksyczne (LOAEL = 31,25 mg/kg). Zaproponowano wartość NDS na poziomie 15 mg/m3, a wartość NDSCh (wartość arbitralna) równą 50 mg/m3. Ze względu na łatwe wchłanianie się DMA przez skórę obie wartości dopuszczalne opisano symbolem „Sk”. Jako DSB zaproponowano stężenie MetHb we krwi równe 2%, tj. wartość zalecaną dla substancji methemoglobinotwórczych. .

EN

N,N-Dimethylaniline (DMA) is used as an organic solvent and half-product for organic syn-thesis. Exposure to this compound in industry is poorly documented. As a result of both single and repeated administration of DMA, in humans as well as animals the following hematotoxic effects can be observed: symptoms of cyanosis, spleen enlargement, methemoglobinemia and extra marrow hematopoesis. DMA has clastogenic effect; its carcinogenic, embryotoxic and teratogenic effects, however, have not been confirmed. The MAC value was estimated on the basis of experiments on rats, which were administered DMA intragastrically, and hematotoxic effect has been observed. Based on LOAEL value obtained from this experiment (31.25 mg/m3) and appropriate uncertainty factors, the MAC value was calculated at 12 mg/m3 and MAC-STEL (arbitrary value) of 40 mg/m3 proposed. Due to easy absorption of DMA through the skin, both allowed values are described as ,,Sk”. Moreover methemoglobin concentration of 2% in peripheral blood as biological exposure index was proposed.

Słowa kluczowe

PL

dimetyloanilina; narażenie zawodowe; działanie rakotwórcze

EN

dimethylaniline; occupational exposure; carcinogenic action

• Wydawca: Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy
• Czasopismo: Podstawy i Metody Oceny Środowiska Pracy
• Rocznik: 2002
• Tom: Nr 3 (33)
• Strony: 103--116
• Opis fizyczny: Bibliogr. 30 poz., rys., tab.

Twórcy

autor

Starek A.

• Collegium Medicum Uniwersytetu Jagiellońskiego 30-688 Kraków ul. Medyczna 9

Bibliografia

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