Ca-deficient hydroxyapatite scaffolds from injectable calcium phosphate/chitosan cements

• Autorzy: Rajzer I. , Castano O. , Engel E. , Planell J. A.
• Języki publikacji: EN

Abstrakty

EN

Calcium phosphate cement (CPC) has been success-fully used in bone tissue regeneration for many years. However, poor mechanical properties and low biodegradation rate limit any further applications. R-cement has a higher solubility than conventional CPC and its reaction products (CDHA) are similar to the mineral phase of bone. In this work we have developed new CPC composition which consists of a mix of cement R, glycerol as a liquid phase carrier and a biodegradable hydrogel (chitosan) which acts as a binder and was incorporated into R-cement to strengthen this biomaterial. The cement past was found to be stable in a syringe (even after two month of storage in the freezer) and hardened only after being exposed to biological fluids.

Słowa kluczowe

EN

calcium phosphate cement; injectability; chitosan

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2010
• Tom: Vol. 13, no. 92
• Strony: 2--4
• Opis fizyczny: Bibliogr. 7 poz., tab., wykr., zdj.

Twórcy

autor

Rajzer I.

• IBEC, Institute for Bioengineering of Catalonia, Biomaterials, Implants and Tissue Engineering Division, Barcelona, Spain
• ATH, University of Bielsko-Biala, Faculty of Materials and Environmental Sciences, Institute of Textile Engineering and Polymer Materials, Department of Polymer Materials, Willowa 2, 43-309 Bielsko-Biała, Poland

autor

Castano O.

• IBEC, Institute for Bioengineering of Catalonia, Biomaterials, Implants and Tissue Engineering Division, Barcelona, Spain
• Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)

autor

Engel E.

• IBEC, Institute for Bioengineering of Catalonia, Biomaterials, Implants and Tissue Engineering Division, Barcelona, Spain
• Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)

autor

Planell J. A.

• IBEC, Institute for Bioengineering of Catalonia, Biomaterials, Implants and Tissue Engineering Division, Barcelona, Spain
• Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)

Bibliografia

• [1] J. L. Moreau, H. H. K. Xu. Mesenchymal stem cell proliferation and differentiation on an injectable calcium phosphate – Chitosan composite scaffold. Biomaterials 2009; 30: 2675-2682.
• [2] S. Takagi et al. Rapid-hardering calcium phosphate cement composition. Patent US7294187, 2007.
• [3] H. H. K. Xu, M.D. Weir, C. G. Simon. Injectable and strong nano-apatite scaffolds for cell/growth factor delivery and bone regeneration. Dental Materials 2008; 24: 1212-1222.
• [4] F.C.M. Driessens et al. The Ca/P range of nanoapatitic calcium phosphate cements. Biomaterials 2002; 23: 4011-4017.
• [5] R. A. A. Muzzarelli, G. Biagini, M. Bellardini, L. Simonelli, C. Castaldini, G. Fraatto. Osteoconduction exerted by methylpyroli-dinone chitosan in dental surgery. Biomaterials 1993; 14: 39-43.
• [6] H. H. K. Xu, C. G. Simon. Fast setting calcium phosphate-chitosan scaffold: mechanical properties and biocompatibility. Biomaterials 2005; 26: 1337-48.
• [7] M.P. Ginebra et al. Setting Reaction and Hardening of an Apatitic Calcium Phosphate Cement. J Dent Res 1997; 76(4): 905-912.