Simultaneous RP-HPLC analysis of atenolol, hydrochlorothiazide, and losartan potassium in a tablet formulation

• Autorzy: Thomas A. B , Chavan U. B , Nanda R. K , Kothapalli L. P , Jagdale S. N , Dighe S. B , Deshpande A. D
• Języki publikacji: EN

Abstrakty

EN

Simultaneous analysis of atenolol (Atn), hydrochlorothiazide (Hctz) and losartan potassium (Los) in solid dosage forms has been achieved by reversed-phase high-performance liquid chromatography on a C 18 column with a 0.035 M potassium dihydrogen orthophosphate-acetonitrile gradient as mobile phase and UV detection at 225 nm. The retention times for Atn, Hctz, and Los were 2.91, 4.75, and 7.52 min, respectively, with mean recoveries of 99.67, 99.89, and 100.69%. The method was validated in accordance with ICH guidelines. Because of its simplicity and high precision and accuracy, the method can be used for analysis of atenolol, hydrochlorothiazide and losartan potassium in pharmaceutical preparations.

Słowa kluczowe

EN

atenolol; hydrochlorothiazide; losartan; HPLC

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2010
• Tom: Vol. 22, no. 2
• Strony: 219--226
• Opis fizyczny: Bibliogr. 14 poz., rys., tab.

Twórcy

autor

Thomas A. B

• Padm Dr D.Y. Patil Institute of Pharmaceutical Sciences and Research Department of Pharmaceutical Chemistry Pimpri, Pune 411018 Maharashtra India

autor

Chavan U. B

• Padm Dr D.Y. Patil Institute of Pharmaceutical Sciences and Research Department of Pharmaceutical Chemistry Pimpri, Pune 411018 Maharashtra India

autor

Nanda R. K

• Padm Dr D.Y. Patil Institute of Pharmaceutical Sciences and Research Department of Pharmaceutical Chemistry Pimpri, Pune 411018 Maharashtra India

autor

Kothapalli L. P

• Padm Dr D.Y. Patil Institute of Pharmaceutical Sciences and Research Department of Pharmaceutical Chemistry Pimpri, Pune 411018 Maharashtra India
• Padm Dr D.Y. Patil Institute of Pharmaceutical Sciences and Research Department of Pharmaceutical Chemistry Pimpri, Pune 411018 Maharashtra India

autor

Jagdale S. N

• Padm Dr D.Y. Patil Institute of Pharmaceutical Sciences and Research Department of Pharmaceutical Chemistry Pimpri, Pune 411018 Maharashtra India

autor

Dighe S. B

• Padm Dr D.Y. Patil Institute of Pharmaceutical Sciences and Research Department of Pharmaceutical Chemistry Pimpri, Pune 411018 Maharashtra India

autor

Deshpande A. D

• Padm Dr D.Y. Patil Institute of Pharmaceutical Sciences and Research Department of Pharmaceutical Chemistry Pimpri, Pune 411018 Maharashtra India

Bibliografia

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• [14] ICH Guidelines Q2B, Validation of Analytical Procedures-Methodology, 1996