Application of an ultra-high dose rate (FLASH) proton beam for the 3D cancer cell model - a proof of concept

• Autorzy: Durak-Kozica Martyna , Stępień Ewa , Swakoń Jan , Moskal Paweł

Identyfikatory

DOI

10.5604/01.3001.0054.1820

• Języki publikacji: EN

Abstrakty

EN

Ultra-high dose rate (FLASH) proton radiotherapy is a promising treatment method for cancer patients. In our research, we want to compare the FLASH method with a conventional radiation method to show what effect they have on the biochemical structure of the tumour (3D model - spheroids) and the secretion of extracellular vesicles (EVs) and their cargo. The use of a modern method of creating spheroids will enable us to create conditions that are better able to mimic the tumour microenvironment.

Słowa kluczowe

EN

FLASH proton radiotherapy; spheroids; melanoma cancer; extracellular vesicles

• Wydawca: Uniwersytet Jagielloński - Collegium Medicum ; Index Copernicus Sp. z o.o.
• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2023
• Tom: Vol. 19, no. 1
• Strony: 31--34
• Opis fizyczny: Bibliogr. 36 poz., rys.

Twórcy

autor

Durak-Kozica Martyna

• Marian Smoluchowski Institute of Physics, Jagiellonian University, Krakow, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0000-0002-5275-6462

autor

Stępień Ewa

• Marian Smoluchowski Institute of Physics, Jagiellonian University, Krakow, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0000-0003-3589-1715

autor

Swakoń Jan

• Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland

• https://orcid.org/0000-0001-9262-7326

autor

Moskal Paweł

• Marian Smoluchowski Institute of Physics, Jagiellonian University, Krakow, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0000-0002-4229-3548

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).