1,1 –Dimetylohydrazyna. Dokumentacja proponowanych wartości dopuszczalnych poziomów narażenia zawodowego

• Autorzy: Starek A.

Warianty tytułu

EN

1,1 Dimethylhvdrazine

• Języki publikacji: PL

Abstrakty

PL

1,1 - Dimetylohydrazyna (UDMH) jest bezbarwną cieczą o zapachu amoniaku. Stosowana jest jako komponent płynnych paliw rakietowych, absorbent kwaśnych gazów, substancja redukująca oraz półprodukt w syntezie organicznej. Narażenie na ten związek występuje podczas magazynowania, transportu i stosowania substancji. Dane na temat toksyczności UDMH u ludzi są niewystarczające. Ostra toksyczność u zwierząt klasyfikuje ten związek do grupy substancji szkodliwych. W warunkach narażenia powtarzanego UDMH działa diuretycznie, immunosupresyjnie, hemolitycznie, pobudzająco lub depresyjnie na ośrodkowy i obwodowy układ nerwowy, a także hepatotoksycznie, nefrotoksycznie i rakotwórczo. Ponadto związek ten wywiera działanie genotoksyczne i mutagenne. W warunkach narażenia przewlekłego efektem krytycznym u psów jest niedokrwistość hemolityczna. Wartość NDS 1,1 -dimetylohydrazyny obliczono na podstawie wyznaczonego doświadczalnie najniższego obserwowanego poziomu działania szkodliwego (LOAEL), wynoszącego 12 mg/m3. Zaproponowano przyjęcie wartości NDS na poziomie 0,1 mg/mJ wraz z oznakowaniem substancji literami Sk, co wskazuje na łatwe wchłanianie związku przez skórę. Nie znaleziono merytorycznych podstaw do zaproponowania wartości NDSCh i DSB 1,1-dimetylohydrazyny.

EN

1,1- Dimethylhydrazine (UDMH) is a colourless liquid with an ammonia odour. This compound is used as a component of racket fuels, absorbent of acidic gases, reducer, and an intermediate in organic synthesis. The acute toxicity of UDMH in animals qualifies this compound as a harmful substance. During repeated exposure UDMH exerted diuretic, immunosuppresive, hemolytic, depressive or exiciting, hepatotoxic, nephrotoxic, and car-cinogenic effects. Moreover, its genotoxic and mutagenic effects have been confirmed. The MAC value of 0,1 mg/m3 was estimated on the basis of the LOAEL value (12 mg/m3) obtained in experiments on dogs (24 weeks) and relevant uncertainty factors. Skin (Sk) notation is recommended.

Słowa kluczowe

PL

1,1-dimetylohydrazyna; narażenie zawodowe; wartości NDS; działanie toksyczne

EN

1,1 dimethylhvdrazine; occupational exposure; MAC-values; toxic effect

• Wydawca: Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy
• Czasopismo: Podstawy i Metody Oceny Środowiska Pracy
• Rocznik: 2003
• Tom: Nr 2 (36)
• Strony: 157--173
• Opis fizyczny: Bibliogr. 42 poz., tab.

Twórcy

autor

Starek A.

• Collegium Medicum Uniwersytetu Jagiellońskiego 30-688 Kraków ul. Medyczna 9

Bibliografia

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