Effect of micro-cracks on the angiogenesis and osteophyte development in degenerative joint disease

• Autorzy: Bednarczyk E. , Lekszycki T. , Glinkowski W.
• Języki publikacji: EN

Abstrakty

EN

Osteoarthritis, one of the most common types of arthritis, is characterized by the development of osteophytes. The main cause of joint degeneration is mechanical loading, but there are also several other factors that influence the development of osteophytes. In order to formulate a mathematical model of bone spurs’ development we have selected the most important factors, such as angiogenesis, micro-damage of the tissue structure and cell signaling. The proposed system of integro-differential equations describes the degenerative changes in the joint. Numerical calculations were implemented into the COMSOL Multiphysics software and the obtained results thus reflect relationships between certain parameters and variables. Additionally, the results correspond with those obtained from medical observations.

Słowa kluczowe

EN

osteoarthritis; angiogenesis; mathematical modelling; mechanical loading; microdamage; osteophyte

PL

choroba zwyrodnieniowa stawu; angiogeneza; modelowanie matematyczne; obciążenie mechaniczne; mikrouszkodzenie; osteofit

• Wydawca: Instytut Podstawowych Problemów Techniki PAN
• Czasopismo: Computer Assisted Methods in Engineering and Science
• Rocznik: 2017
• Tom: Vol. 24, no. 3
• Strony: 149--156
• Opis fizyczny: Bibliogr. 21 poz., rys., wykr.

Twórcy

autor

Bednarczyk E.

• Faculty of Production Engineering Warsaw University of Technology Narbutta 85, 02-524 Warsaw

autor

Lekszycki T.

• Faculty of Production Engineering Warsaw University of Technology Narbutta 85, 02-524 Warsaw;4Q
• Department of Experimental Physiology and Pathophysiology Medical University of Warsaw Pawińskiego 3c, 02-106 Warsaw, Poland

autor

Glinkowski W.

• Department of Orthopedics and Traumatology of the Locomotor System Baby Jesus Clinical Hospital Lindleya 4, 02-005 Warsaw, Poland
• Department of Medical Informatics and Telemedicine Medical University of Warsaw Banacha 1a, 02-097 Warsaw, Poland

Bibliografia

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