Implementation and evaluation of new protocol for comparative modeling of protein structures

• Autorzy: Strumillo M. , Dawid A. E. , Szczasiuk A. , Gront D.
• Języki publikacji: EN

Abstrakty

EN

Template-based modeling (termed also Comparative or Homology Modeling) of a protein structure is one of ubiquitous tasks of structural bioinfor matics. The method can deliver model structures important for testing biological hypotheses, virtual docking and drug design. The performance of these methods is evaluated every two years during a Critical Assessment of Protein Structure Prediction (CASP) experiment. In this contribution we present a new automated protocol for template-base d modeling, which combines computational tools recently developed in our laboratory: the dat abase of protein domain structures (BDDB) with one dimensional and three dimensional thread ing applications. The protocol was tested during a CASP11 experiment.

Słowa kluczowe

EN

protein structure prediction; comparative modeling; protein threading; protein alignment; BioShell; Rosetta

PL

przewidywanie struktury białek; modelowanie porównawcze; gwintowania białka; wyrównanie białka; BioShell; Rosetta

• Wydawca: Politechnika Gdańska
• Czasopismo: TASK Quarterly : scientific bulletin of Academic Computer Centre in Gdansk
• Rocznik: 2014
• Tom: Vol. 18, No 4
• Strony: 379--384
• Opis fizyczny: Bibliogr. 18 poz., rys., wykr.

Twórcy

autor

Strumillo M.

• Laboratory of Theory of Biopolymers, Faculty of Chemistry University of Warsaw Pasteura 1, 02-093 Warsaw, Poland

autor

Dawid A. E.

• Laboratory of Theory of Biopolymers, Faculty of Chemistry University of Warsaw Pasteura 1, 02-093 Warsaw, Poland

autor

Szczasiuk A.

autor

Gront D.

Bibliografia

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