Antibacterial effect of polylactic-co-glycolic acid/selenium nanocomposite against dental biofilm

• Autorzy: Safaei Mohsen , Khaleseh Farnoosh , Ahmadi Saba , Mobarakeh Mohammad Salmani , Law Douglas , Wong Ling Shing , Ravinder D. , Nhlapo Amos , Hashim Mohd , Parveen Azra

Identyfikatory

DOI

10.14314/polimery.2025.3.4

Warianty tytułu

PL

Działanie antybakteryjne nanokompozytu poli(kwasu mlekowego-co-glikolowego) z selenem na biofilm zębowy

• Języki publikacji: EN

Abstrakty

EN

To determine the optimal conditions for obtaining poly(lactic-co-glycolic) acid with selenium (PLGA/selenium) nanocomposites the Taguchi method was used. FT-IR, Raman spectroscopy, XRD and FESEM analysis confirmed the nanocomposites’ structure. The nanocomposite containing 6 mg/mL of selenium obtained in the process where the mixing time was 75 min showed the highest antibacterial activity against Streptococcus mutans. The obtained nanocomposites are an innovative approach to im-proving oral health and can be used as antibacterial materials for medical and dental applications.

PL

Metodą Taguchi określono optymalne warunki otrzymywania nanokompozytów poli(kwasu mlekowego-co-glikolowego) z selenem (PLGA/selen) i oceniono ich aktywność przeciwbakteryjną przeciwko Streptococcus mutans. Najwyższą aktywnością przeciwbakteryjną charakteryzował się nanokompozyt zawierający 6 mg/mL selenu (czas mieszania 75 min). Strukturę nanokompozytu potwierdzono metodą FT-IR, spektroskopii Ramana, XRD i FESEM. Nanokompozyty PLGA/selen stanowią nowe podejście do poprawy zdrowia jamy ustnej i mogą być stosowane jako materiały przeciwbakteryjne do zastosowań medycznych i stomatologicznych.

Słowa kluczowe

EN

poly(lactic-co-glycolic acid); selenium; nanocomposite; Streptococcus mutans; human health; Taguchi method

PL

kwas poli(mlekowy-co-glikolowy); selen; nanokompozyt; Streptococcus mutans; ludzkie zdrowie; metoda Taguchi

• Wydawca: Sieć Badawcza Łukasiewicz – Instytut Chemii Przemysłowej
• Czasopismo: Polimery
• Rocznik: 2025
• Tom: Vol. 70, nr 3
• Strony: 186--193
• Opis fizyczny: Bibliogr. 20 poz., rys., tab., wykr.

Twórcy

autor

Safaei Mohsen

• Division of Dental Biomaterials, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 54658, Iran
• Advanced Dental Sciences and Technology Research Center, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 38647, Iran

• https://orcid.org/0000-0003-3885-6640

autor

Khaleseh Farnoosh

• Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

• https://orcid.org/0009-0004-4610-198X

autor

Ahmadi Saba

• Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

• https://orcid.org/0009-0006-4100-1714

autor

Mobarakeh Mohammad Salmani

• Advanced Dental Sciences and Technology Research Center, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 38647, Iran

• https://orcid.org/0000-0002-3272-6640

autor

Law Douglas

• Faculty of Health and Life Sciences, INTI International University, Nilai 71800, Malaysia

• https://orcid.org/0000-0002-7824-3542

autor

Wong Ling Shing

• Faculty of Health and Life Sciences, INTI International University, Nilai 71800, Malaysia

• https://orcid.org/0000-0002-9571-0804

autor

Ravinder D.

• Department of Physics, Osmania University, Telangana, 500007, Hyderabad, India

• https://orcid.org/0000-0002-0626-3034

autor

Nhlapo Amos

• Department of Medical Physics, Sefako Makgatho Health Sciences University, P. O. Box 146, Medunsa 0204, South Africa

• https://orcid.org/0000-0001-5670-4056

autor

Hashim Mohd

• Department of Applied Physics, Aligarh Muslim University, Aligarh, India

• https://orcid.org/0000-0003-0231-0697

autor

Parveen Azra

• Department of Applied Physics, Aligarh Muslim University, Aligarh, India

• https://orcid.org/0000-0003-2444-3503

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