Synteza i aktywność biologiczna pochodnych pirolo[2,3-d]pirydazyny

• Autorzy: Redzicka A. , Tylińska B.

Warianty tytułu

EN

Synthesis and biological activity of pyrrolo[2,3-d]pyridazine derivatives

• Języki publikacji: PL

Abstrakty

EN

Pyrrolo[2,3-d]pyridazines are one of the four structural isomers of the bicyclic ring system containing pyrrole moiety condensed with a pyridazine ring. This review presents most of the literature data about synthetic pyrrolo[2,3-d]pyridazine derivatives and their biological activity. These 5,6-diazaindole analogues were first synthesized by Fischer et. al. in 1928. Compounds containing the pyrrolo[2,3-d] pyridazine scaffold can be synthesized from different substrates, but the syntheses may be classified into two main categories: annulation of pyrrole ring on to pyridazine derivatives or annulation of pyridazine ring on to pyrrole derivatives. Pyrrolo[2,3-d]pyridazine derivatives have attracted considerable interest, owing to diverse biological activities. Most of them have been studied as antitumor and antiviral. Pyrrolo[2,3-d]pyridazines can also be used as acid pump antagonist.

Słowa kluczowe

PL

pochodne pirolo[2,3-d]pirydazyny; aktywność biologiczna; synteza

EN

pyrrolo[2,3-d]pyridazine derivatives; biological activity; synthesis

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2016
• Tom: [Z] 70, 3-4
• Strony: 141--161
• Opis fizyczny: Bibliogr. 29 poz., schem., tab.

Twórcy

autor

Redzicka A.

• Katedra i Zakład Chemii Leków Uniwersytetu Medycznego we Wrocławiu ul. Borowska 211, 50-556 Wrocław

autor

Tylińska B.

• Katedra i Zakład Chemii Organicznej Uniwersytetu Medycznego we Wrocławiu ul. Borowska 211a, 50-556 Wrocław

Bibliografia

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Uwagi

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę.