Numerical simulation of non-linear loading– unloading hysteresis behavior of blood clots

• Autorzy: Tashiro Koichiro , Shobayashi Yasuhiro , Hotta Atsushi

Identyfikatory

DOI

10.1016/j.bbe.2022.10.002

• Języki publikacji: EN

Abstrakty

EN

The stress-strain characteristics of a clot during loading/unloading mechanical cycles are significant features to assess the underlying mechanisms of thrombectomy, especially when multiple thrombectomy attempts are required. We investigated a damage model to predict loading/unloading response of clots. To study the validity of the model, we tested theoretical models to reproduce the experimentally obtained mechanical characteristics of clots under various conditions. Three types of clot analogs with different red blood cell (RBC) compositions were prepared. Cylindrical clot analogs were formed for the tensile and compression tests. Loading/unloading tests at 80% of strain were conducted, where the material parameters were determined by fitting the results to a theoretical curve combining the damage model and the elasto-plastic constitutive model. Through the computation for theoretical curves, unique characteristics of clots were revealed such that the hysteresis loss rate did not change by varying RBC contents, except for the clot created with 0% RBC composition, under compressive loading. In addition, the plastic strain decreased as the RBC content decreased under tensile loading, whereas it increased as the RBC content decreased under compressive loading. A three-dimensional finite element method (FEM) was employed with the determined parameters. The FEM could accurately reproduce the experimental stress-strain curves for all types of clot analogs and for both loading types up to a strain of 80%. The results indicate that the theoretical model which incorporates and combines the damage model and the elasto-plastic constitutive model is applicable to predict the non-linear stress–strain behavior of clots under loading and unloading.

Słowa kluczowe

EN

acute ischemic stroke; AIS; mechanical thrombectomy; blood clotting; damage model; hysteresis loss; finite element analysis; FEM

PL

udar niedokrwienny; AIS; trombektomia mechaniczna; krzepnięcie krwi; analiza elementów skończonych; FEM

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2022
• Tom: Vol. 42, no. 4
• Strony: 1205--1217
• Opis fizyczny: Bibliogr. 56 poz., rys., tab., wykr.

Twórcy

autor

Tashiro Koichiro

• Department of Mechanical Engineering, Keio University, Hiyoshi, Kohoku-ku, Yokohama, Japan
• Biomedical Solutions Inc., Nihombashihon-cho, Chuo-ku, Tokyo, Japan

autor

Shobayashi Yasuhiro

• Biomedical Solutions Inc., Nihombashihon-cho, Chuo-ku, Tokyo, Japan

autor

Hotta Atsushi

• Department of Mechanical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan

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Uwagi

PL

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023)