Toxicity evaluation of methacryloyloxyethyl phosphorylcholine/selenium nanocomposite on oral squamous cell carcinoma

• Autorzy: Safaei Mohsen , Khaleseh Farnoosh , Pourahmadi Mehrnaz , Ling Shing Wong

Identyfikatory

DOI

10.14314/polimery.2025.6.4

Warianty tytułu

PL

Ocena cytotoksyczności nanokompozytu metakryloyloksyetylofosforylocholina/selen w stosunku do raka płaskonabłonkowego jamy ustnej

• Języki publikacji: EN

Abstrakty

EN

The Taguchi method was used to determine the optimal conditions for obtaining methac-ryloyloxyethylphosphorylcholine/selenium (MPC/selenium) nanocomposites and to investigate their anticancer activity on oral squamous cell carcinoma (OSCC) cells. The MTT test was used to assess the cytotoxicity and viability of OSCC cells at different concentrations of MPC/selenium. Due to their high anticancer activity (94.9%), the developed nanocomposites can be used as new therapeutic agents in the treatment of oral squamous cell carcinoma.

PL

Metodą Taguchi określono optymalne warunki otrzymywania nanokompozytów meta-kryloyloksyetylofosforylocholina/selen (MPC/selen) i zbadano ich aktywność przeciwnowotworową na komórki płaskonabłonkowego raka jamy ustnej (OSCC). Do oceny cytotoksyczności i żywotności komórek OSCC, przy różnych stężeniach MPC/selen, stosowano test MTT. Ze względu na wysoką aktywność przeciwnowotworową (94,9%) opracowane nanokompozyty mogą znaleźć zastosowanie jako nowe środki terapeutyczne w leczeniu płaskonabłonkowego raka jamy ustnej.

Słowa kluczowe

EN

methacryloyloxyethyl phosphorylcholine; selenium nanoparticles; human health; oral cancer; Taguchi method

PL

metakryloyloksyetylofosforylocholina; nanocząstki selenu; ochrona zdrowia; nowotwór jamy ustnej; metoda Taguchi

• Wydawca: Sieć Badawcza Łukasiewicz – Instytut Chemii Przemysłowej
• Czasopismo: Polimery
• Rocznik: 2025
• Tom: Vol. 70, nr 6
• Strony: 394--401
• Opis fizyczny: Bibliogr. 28 poz., rys., tab., wykr.

Twórcy

autor

Safaei Mohsen

• Division of Dental Biomaterials, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 54658, Iran
• Advanced Dental Sciences and Technology Research Center, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 38647, Iran

• https://orcid.org/0000-0003-3885-6640

autor

Khaleseh Farnoosh

• Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

• https://orcid.org/0009-0004-4610-198X

autor

Pourahmadi Mehrnaz

• Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

• https://orcid.org/0009-0000-8378-7889

autor

Ling Shing Wong

• Faculty of Health and Life Sciences, INTI International University, Nilai 71800, Malaysia

• https://orcid.org/0000-0002-5869-0804

Bibliografia

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