Optimization and validation of a new high-performance liquid chromatographic method for analysis of acetazolamide in tablets using Box-Behnken statistical experiment design

• Autorzy: Ihssane B , Charrouf M , Abourriche A , Abboud Y , Bouabidi A , Bennamara A , Saffaj T
• Języki publikacji: EN

Abstrakty

EN

This paper describes the optimization and validation of an analytical method for HPLC analysis of acetazolamide in tablets using Box-Behnken design. This multivariate approach enables substantial improvement of chromatographic performance using fewer experiments, without additional cost of columns or other equipment. By use of quadratic regression analysis, equations were developed describing the behavior of the response as simultaneous functions of the selected independent variables. Accordingly, the optimum conditions were determined. For quality-control samples these were use of a C18 column with acetonitrile-phosphoric acid buffer solution (0.01 M, pH 7.1) 15:85 (ν/ν) as mobile phase at a flow rate of 1.0 mL min^-1 Diode-array detection was performed at 266 nm. The method was validated, in accordance with ICH guidelines, for accuracy, precision (intra-day and inter-day coefficient of variation <2.0%), selectivity, and linearity (R2 = 0.9993) over the concentration range 10–300 μg mL. ^-1 The method is simple, rapid, sensitive, and accurate and the retention time is less than 4 min. The method is therefore suitable for routine quality-control monitoring of acetazolamide in tablets.

Słowa kluczowe

EN

response surface methodology; acetazolamide; validation; optimization; tablets formulation

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2011
• Tom: Vol. 23, no. 1
• Strony: 41--57
• Opis fizyczny: Bibliogr. 45 poz., rys., tab.

Twórcy

autor

Ihssane B

• University Hassan II — Mohammedia, Faculty of Science Ben M’sik Biomolecular and Organic Synthesis Laboratory Associated with CNR Avenue Cdt D. El Harti BP 7955 Casablanca Morocco

autor

Charrouf M

• University Hassan II — Mohammedia, Faculty of Science Ben M’sik Biomolecular and Organic Synthesis Laboratory Associated with CNR Avenue Cdt D. El Harti BP 7955 Casablanca Morocco

autor

Abourriche A

• University Hassan II — Mohammedia, Faculty of Science Ben M’sik Biomolecular and Organic Synthesis Laboratory Associated with CNR Avenue Cdt D. El Harti BP 7955 Casablanca Morocco

autor

Abboud Y

• University Hassan II — Mohammedia, Faculty of Science Ben M’sik Biomolecular and Organic Synthesis Laboratory Associated with CNR Avenue Cdt D. El Harti BP 7955 Casablanca Morocco

autor

Bouabidi A

• University Hassan II — Mohammedia, Faculty of Science Ben M’sik Analytical Chemistry Laboratory Casablanca Morocco

autor

Bennamara A

• University Hassan II — Mohammedia, Faculty of Science Ben M’sik Biomolecular and Organic Synthesis Laboratory Associated with CNR Avenue Cdt D. El Harti BP 7955 Casablanca Morocco

autor

Saffaj T

• University Sidi Mohamed Ben Abedallah Regional University Center of Interface BP 2626 route d’immouzer-Fès Morocco

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