Inhibitory cholinoesteraz w terapii choroby Alzheimera

Zawadzka, A.; Czarnocki, Z.

Artykuł - szczegóły

Tytuł artykułu

Inhibitory cholinoesteraz w terapii choroby Alzheimera

Autorzy

Zawadzka A. , Czarnocki Z.

Treść / Zawartość

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Identyfikatory

Warianty tytułu

Cholinesterase inhibitors in Alzheimer disease therapy

Języki publikacji

Abstrakty

In recent years, a progressive increase in age-related disorders could be observed in most western countries, among which Alzheimer’s disease (AD) is one of the most challenging. The progress of AD is characterized by a severe loss in memory and cognition, leading to behavioral changing, depression and death. Currently approved treatments, including the acetylcholinesterase inhibitors (AChEIs) donepezil, galantamine and rivastigmine and N-methyl-d-aspartate (NMDA) antagonist memantine, do not halt the progression of the disease. The discovering of multifunctional compounds considering that several dual binding site AChEIs were able to reach different targets, guided the development of new drug design strategy, the multi-target-directed ligand (MTDL) approach. This review shows briefly summaries past and present research on the cholinesterase inhibitors (ChIs) able to interact with other targets contributing in aetiology of Alzheimer’s disease.

Słowa kluczowe

choroba Alzheimera inhibitory cholinoesteraz leki hybrydowe związki o wielokierunkowym działaniu

Alzheimer's disease cholinesterase inhibitors hybrid drugs multi target directed ligands MTDLs

Wydawca

Polskie Towarzystwo Chemiczne

Czasopismo

Wiadomości Chemiczne

Rocznik

2015

Tom

[Z] 69, 9-10

Strony

767--788

Opis fizyczny

Bibliogr. 120 poz., schem.

Twórcy

autor

Zawadzka A.

azawadzka@chem.uw.edu.pl

Wydział Chemii Uniwersytetu Warszawskiego ul. Pasteura 1, 02-093 Warszawa

autor

Czarnocki Z.

Wydział Chemii Uniwersytetu Warszawskiego ul. Pasteura 1, 02-093 Warszawa

Bibliografia

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