Interactions of Some Organic Solvents: Hydrocarbons and Chloroalkene

• Autorzy: Skowroń J. , Miranowicz-Dzierżawska K. , Zapór L. , Gołofit-Szymczak M. , Starek A.
• Języki publikacji: EN

Abstrakty

EN

Metabolic and toxicodynamic interactions of some organic solvents in rats repeatedly treated with medium dose levels were examined. It was shown that both n-hexane and ethylbenzene significantly inhibited tetrachloroethylene metabolism during a 2-week period. n-Hexane and tetrachloroethylene enhanced metabolism of ethylbenzene whereas ethylbenzene suppressed n-hexane metabolism only at the end of the experiment. Biochemical changes, especially the drop in the level of non-protein sulfhydryl groups in tissues of rats treated with organic solvent mixtures, were significantly less pronounced than those observed after these chemicals were administered separately. These results demonstrate that metabolic interactions between hydrocarbons and chloroalkene may lead to a modification of the biological response to these compounds.

Słowa kluczowe

EN

n-hexane; ethylbenzene; tetrachloroethylene; metabolic interactions; toxicodynamic interactions

PL

interakcje metaboliczne; tetrachloroetylen; etylobenzen

• Wydawca: Taylor & Francis
• Czasopismo: International Journal of Occupational Safety and Ergonomics
• Rocznik: 2001
• Tom: Vol. 7, No. 1
• Strony: 35--47
• Opis fizyczny: Bibliogr. 28 poz., wykr.

Twórcy

autor

Skowroń J.

• Department of Chemical and Aerosol Hazards, Central Institute for Labour Protection, Warsaw, Poland

autor

Miranowicz-Dzierżawska K.

• Department of Chemical and Aerosol Hazards, Central Institute for Labour Protection, Warsaw, Poland

autor

Zapór L.

• Department of Chemical and Aerosol Hazards, Central Institute for Labour Protection, Warsaw, Poland

autor

Gołofit-Szymczak M.

• Department of Chemical and Aerosol Hazards, Central Institute for Labour Protection, Warsaw, Poland

autor

Starek A.

• Collegium Medicum, Jagiellonian University, Cracow, Poland

Bibliografia

• 1.Abou-Donia, M.B., Makkaway, H.M., & Graham, D.H. (1982). The relative neurotoxity of n-hexane, methyl n-butylketone, 2,5-hexanediol and 2,5-hexanedione following oral or intraperitoneal administration in hens. Toxicology and Applied Pharmacology, 62, 369-376.
• 2.Altenkirch, H., Stoltenberg, G., & Wagner, H.N. (1978). Experimental studies on hydrocarbon neuropathies induced by methyl ethyl ketone (MEK). Journal of Neurology, 219, 159-170.
• 3.Buben, J.A., & O’Flaherty, E.J. (1985). The lineation of the role of metabolism in the hapatotoxicity of trichloroethylene and perchlororthylene. A dose-effect study. Toxicology and Applied Pharmacology, 78, 105-122.
• 4.Daniel J.W. (1963). The metabolism of 36Cl-labelled trichlorothylene and tetrachlorothylene in the rat. Biochemical Pharmacology, 12, 795-802.
• 5.Elovaara, E., Engström, K., Nickels, J., Aito, A., & Vainio, H. (1985). Biochemical and morphological effects of long-term inhalation exposure of rats to ethylbenzene. Xenobiotica, 15(4), 299-308.
• 6.Engström, K.M. (1984). Metabolism of inhaled ethylbenzene in rats. Scandinavian Journal of Work, Environment and Health, 10, 83-87.
• 7.Engström, K., Riihimäki, V., & Laine, A. (1984). Urinary disposition of ethylbenzene and m-xylene in man following separate and combined exposure. International Archives of Occupational and Environmental Health, 54, 355-363.
• 8.Gerlach, U. (1963). Sorbitol dehydrogenase. In H.U. Bergmeyer (Ed.), Methods of enzymatic analysis (pp. 761-764). Weinheim, Germany, and New York, NY, USA: Verlag Chemie and Academic Press.
• 9.Iwata, M., Takeuchi, Y., Hisanaga, N., & Ono, Y. (1983). Changes of n-hexane metabolites in urine of rats exposed to various concentrations of n-hexane and its mixture with toluene or MEK. International Archives of Occupational and Environmental Health, 53, 1-8.
• 10.Iwata, M., Takeuchi, Y., Hisanaga, N., & Ono, Y. (1984). Changes of n-hexane neurotoxicity and its urinary metabolites by long-term co-exposure with MEK or toluene. International Archives of Occupational and Environmental Health, 54, 273-281.
• 11.Jorgensen, N.K., & Cohr, K.H. (1981). n-Hexane and its toxicologic effects. Scandinavian Journal of Work, Environment and Health, 7, 157-168.
• 12.Marth, E. (1987). Metabolic changes following oral exposure to tetrachloroethylene in subtoxic concentrations. Archives of Toxicology, 60, 293-299.
• 13.Mihara, M., Uchiyama, M., & Fukuzawa, K. (1980). Thiobarbituric acid value on fresh homogenate of rat as a parameter of lipid peroxidation in aging CCl4 intoxication and vitamin E deficiency. Biochemical Medicine, 23, 302-311.
• 14.Mitchell, J.R., Snodgrass, W.R., & Gillette, J.R. (1976). The role of biotransformations in chemical-induced liver injury. Environmental Health Perspectives, 15, 27-35.
• 15.Monster, A.C. (1979). Differences in uptake elimination and metabolism in exposure to trichloroethylene, 1,1,1-trichloroethane and tetrachloroethylene. International Archives of Occupational and Environmental Health, 42, 311-317.
• 16.Ogata, M., Tomokuni, K., & Asahara, H. (1974). Simple microdetermination of trichloroethanol glucuronide and trichloroacetic acid in urine. International Archives of Arbeitsmedicine, 32, 203-215.
• 17.Ogata, M., Tomokuni, K., & Takatsuka, Y. (1969). Quantitative determination in urine of hippuric acid and m- or p-methylhippuric acid, metabolites of toluene and m- or p-xylene. British Journal of Industrial Medicine, 26, 330-334.
• 18.Orłowski, M., & Meister, A. (1965). Isolation of gamma-glutamyl-transpeptidase from hog kidney. Journal of Biological Chemistry, 240, 339-343.
• 19.Perbellini, L., De Grandis, D., Sementzato, F., Rizzuto, N., & Simonati, A. (1978). An experimental study on the neurotoxicity of n-hexane metabolites; hexanol-1 and hexanol-2. Toxicology and Applied Pharmacology, 46(2), 421-427.
• 20.Saito, I., Shibata, E., Huang, J., Hisanaga, N., Ono, Y., & Takeuchi, Y. (1991). Determination of urinary 2,5-hexanedione concentration by an improved analytical method as an index of exposure to n-hexane. British Journal of Industrial Medicine, 48, 568-574.
• 21.Schmidt, E. (1963). Glutamic dehydrogenase. In H.U. Bergmeyer (Ed.), Methods of enzymatic analysis (pp. 752-756). Weinheim, Germany, and New York, NY, USA: Verlag Chemie and Academic Press.
• 22.Sedlak, J., & Lindsay, R.H. (1968). Estimation of total protein-bound and non-protein sulfhydryl groups in tissue with Ellman’s reagent. Analytical Biochemistry, 25, 192-205.
• 23.Soni, M., Nomiyama, H., & Nomiyama, K. (1990). Chronic inhalation effects of tetrachloroethylene on hepatic and renal microsomal electron transport components and δ-aminolevulinic acid dehydratase in rats. Toxicology Letters, 54, 207-213.
• 24.Stacey, N.H. (1989). Toxicity of mixtures of trichloroethylene, tetrachloroethylene and 1,1,1-trichloroethane: Similarity of in vitro to in vivo responses. Toxicology and Industrial Health, 5(3), 441-450.
• 25.Starek A. (1998). Interactions between trichloroethylene and tetrachloroethylene in rats. Acta Poloniae Toxicologica, 6, 199-207.
• 26.Takeuchi, Y., Hisanaga, N., Ono, Y., Shibata, E., Saito, I., & Iwata, M. (1993). Modification of metabolism and neurotoxicity of hexane by co-exposure of toluene. International Archives of Occupational and Environmental Health, 65, 227-230.
• 27.Takeuchi, Y., Ono, Y., Hisanaga, N., Iwata, M., Aoyama, M., Kitoh, J., & Sugiura, Y. (1983). An experimental study of the combined effects of n-hexane and methyl ethyl ketone. British Journal of Industrial Medicine, 40, 199-203.
• 28.Wesołowski, W., & Gromiec, J.P. (1997). Occupational exposure in Polish paints and lacquer industry. International Journal of Occupational Medicine and Environmental Health, 10, 79-88.