Synthesis, Characterization and Biological evaluation of some newer 5-[6-chloro/fluoro/nitro-2-(p-chloro/ fluoro/ methyl phenyl)-quinolin-4-yl]-1,3,4-oxadiazole-2-thiols

• Autorzy: Faldu V. J. , Talpara P. K. , Bhuva N. H. , Vachharajani P. R. , Shah V. H.
• Języki publikacji: EN

Abstrakty

EN

Recent study shows that quinolines represent one of the most active classes of compounds possesses wide spectrum biodynamic activities and use as potent therapeutic agents. In present research work, 5-[6-chloro/fluoro/nitro-2-(p-chloro/fluoro/methyl phenyl)-quinolin-4-yl]-1,3,4-oxadiazole-2-thiols have been synthesized by condensation of substituted quinoline-4-carbohydrazides and mixture of carbon disulphide and potassium hydroxide. All of these compounds were screened for their in vitroanti microbial assay against gram (+ve), gram (-ve) bacteria and fungi activity compared with standard drugs viz., Ampicilin, Chloramphenicol, Ciprofloxacin, Norfloxacin, Griseofulvin and Nystatin at different concentrations.

Słowa kluczowe

EN

Quinolines; 1,3,4-oxadiazole-2-thiols; therapeutic agents; antimicrobial assai

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2014
• Tom: Vol. 6
• Strony: 26--32
• Opis fizyczny: Bibliogr. 21 poz., tab., wz.

Twórcy

autor

Faldu V. J.

• Department of Chemistry, Saurashtra University, University Road, Rajkot 360 005, Gujarat, India

autor

Talpara P. K.

• Department of Chemistry, Saurashtra University, University Road, Rajkot 360 005, Gujarat, India

autor

Bhuva N. H.

• Department of Chemistry, Saurashtra University, University Road, Rajkot 360 005, Gujarat, India

autor

Vachharajani P. R.

• Department of Chemistry, Saurashtra University, University Road, Rajkot 360 005, Gujarat, India

autor

Shah V. H.

• Department of Chemistry, Saurashtra University, University Road, Rajkot 360 005, Gujarat, India

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