PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
Tytuł artykułu

Nutritional Benefits and Antihyperglycemic Potential of Carob Fruit (Ceratonia siliqua L.): An Overview

Treść / Zawartość
Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Carob (Ceratonia siliqua L.), a plant native to the Mediterranean, is a member of the legume family and its fruit is called a pod. The flesh of the pod (pulp) is very rich in sugar, while the seeds are high in protein. The pod is also a good source of minerals such as potassium, calcium and phosphorus. It is rich in polyphenols and antioxidants. Due to its nutritional composition, it is suitable for improving human well-being. This article reviews the chemical composition of locust bean fruit and its biological effects on human health. Understanding the traditional uses of locust bean fruit in relation to its potential as an anti-diabetic agent is important in view of the numerous recent scientific studies on its pharmacological properties. The study focuses on in vivo and in vitro antihyperglycemic research, as well as the nutritional profile and potential food applications of this natural product for food formulation and fortification. Based on its chemical and pharmacological properties, this species is believed to have beneficial preventive and therapeutic effects, particularly in hyperglycemia. Researchers can further extract and isolate bioactive compounds from different carob fractions to develop pharmaceutical products and functional foods for the food and pharmaceutical industries.
Twórcy
autor
  • Agri-food Technologies and Quality Laboratory, Regional Center of Agricultural Research of Tadla, National Institute of Agricultural Research, Avenue Ennasr, BP 415 Rabat Principal, Rabat 10090, Morocco
  • Environmental, Ecological, and Agro-Industrial Engineering Laboratory, Faculty of Science and Technology, Beni Mellal, Moulay Slimane University, Beni Mellal, Morocco
  • Institute of Food Science and Nutrition, University of Sargodha, Sargodha 41000, Pakistan
  • Vegetable and Microbial Biotechnology, Biodiversity and Environment, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10000, Morocco
  • National Institute of Agricultural Research, Avenue Ennasr, BP 415 Rabat principal, Rabat 10090, Morocco
  • Institute of Food Science and Nutrition, University of Sargodha, Sargodha 41000, Pakistan
autor
  • Institute of Food Science and Nutrition, University of Sargodha, Sargodha 41000, Pakistan
  • Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi, 44000, Pakistan
autor
  • Agri-food Technologies and Quality Laboratory, Regional Center of Agricultural Research of Tadla, National Institute of Agricultural Research, Avenue Ennasr, BP 415 Rabat Principal, Rabat 10090, Morocco
  • Environmental, Ecological, and Agro-Industrial Engineering Laboratory, Faculty of Science and Technology, Beni Mellal, Moulay Slimane University, Beni Mellal, Morocco
  • Agri-food Technologies and Quality Laboratory, Regional Center of Agricultural Research of Tadla, National Institute of Agricultural Research, Avenue Ennasr, BP 415 Rabat Principal, Rabat 10090, Morocco
Bibliografia
  • 1. Ajebli M. & Eddouks M. 2018. The promising role of plant tannins as bioactive antidiabetic agents. Current Medicinal Chemistry, 26(25), 4852–4884.
  • 2. AL-Saeed M.H., Kadhem M.A. & AL-Saeed A.H. 2019. Study the effect of ethanolic extract of Ceratonia siliqua, Glimephan and metformin on semen fluid quality in diabetic male guinea pig induced by alloxan. Basrah Journal of Veterinary Research, 18(2), 208-233.
  • 3. Arribas C., Cabellos B., Guillamón E. & Pedrosa M.M. 2020. Cooking and sensorial quality, nutritional composition and functional properties of cold-extruded rice/white bean gluten-free fettuccine fortified with whole carob fruit flour. Food & Function, 11(9), 7913–7924.
  • 4. Arribas, C., Pereira E., Barros L., Alves M.J., Calhelha. R.C., Guillamón E., Pedrosa M.M. & Ferreira I.C.F.R. 2019. Healthy novel gluten-free formulations based on beans, carob fruit and rice: Extrusion effect on organic acids, tocopherols, phenolic compounds and bioactivity. Food Chemistry, 292, 304–313.
  • 5. Barak S. & Mudgil D. 2014. Locust bean gum: Processing, properties and food applications-A review. International Journal of Biological Macromolecules, 66, 74–80.
  • 6. Basharat Z., Afzaal M., Saeed F., Islam F., Hussain M., Ikram A., Pervaiz M.U. & Awuchi C.G. 2023. Nutritional and functional profile of carob bean (Ceratonia siliqua L.): a comprehensive review. International Journal of Food Properties, 26(1), 389–413.
  • 7. Boublenza I., Boublenza I., Boublenza A., Madji S., Fabiano-Tixier A.S. & Chemat F. 2019. Carob as source for sustainable ingredients and products. Plant Based “Green Chemistry 2.0” Moving from Evolutionary to Revolutionary, 257–275.
  • 8. Boublenza I., Lazouni H.A., Ghaffari L., Ruiz K., Fabiano-Tixier A.S. & Chemat F. 2017. Influence of roasting on sensory, antioxidant, aromas, and physicochemical properties of carob pod powder (Ceratonia siliqua L.). Journal of Food Quality.
  • 9. Brassesco M.E., Brandão T.R.S., Silva C.L.M. & Pintado M. 2021. Carob bean (Ceratonia siliqua L.): A new perspective for functional food. Trends in Food Science & Technology, 114, 310–322.
  • 10. Cavdarova M. & Makris D.P. 2014. Extraction kinetics of phenolics from carob (Ceratonia siliqua L.) kibbles using environmentally benign solvents. Waste and Biomass Valorization, 5(5), 773–779.
  • 11. Chao E.C. & Henry R.R. 2010. SGLT2 inhibition--a novel strategy for diabetes treatment. Nature Reviews. Drug Discovery, 9(7), 551–559.
  • 12. Christou C., Poulli E., Yiannopoulos S. & Agapiou A. 2019. GC–MS analysis of D-pinitol in carob: Syrup and fruit (flesh and seed). Journal of Chromatography B, 1116, 60–64.
  • 13. Corsi L., Avallone R., Cosenza F., Farina F., Baraldi C. & Baraldi M. 2002. Antiproliferative effects of Ceratonia siliqua L. on mouse hepatocellular carcinoma cell line. Fitoterapia, 73(7–8), 674–684.
  • 14. Dahmani W., Elaouni N., Abousalim A., Akissi Z.L.E., Legssyer A., Ziyyat A. & Sahpaz S. 2023. Exploring carob (Ceratonia siliqua L.): A comprehensive assessment of its characteristics, ethnomedicinal uses, phytochemical aspects, and pharmacological activities. Plants, 12(18), 3303.
  • 15. Darwish W.S., Khadr A.E.S., Kamel M.A.E.N., Abd Eldaim M.A., El Sayed I.E.T., Abdel-Bary H. M., Ullah, S., & Ghareeb, D.A. 2021. Phytochemical characterization and evaluation of biological activities of egyptian carob pods (Ceratonia siliqua L.) Aqueous Extract: In Vitro Study, 10(12), 2626.
  • 16. Elfazazi K., Jbilou M., Assaidi A., Benbati M. & Harrak H. 2017. Morphological and biochemical variability of moroccan carob (Ceratonia siliqua L.) produced in Beni Mellal Region. International Journal of Pure & Applied Bioscience, 5(4), 14–21.
  • 17. Elfazazi K., Harrak H., Achchoub M., & Benbati M. 2020. Physicochemical criteria, bioactive compounds and sensory quality of Moroccan traditional carob drink. Materials Today: Proceedings, 27(July 2021), 3249–3253.
  • 18. El-Haskoury R., Al-Waili N., El-Hilaly J., Al-Waili W. & Lyoussi, B. 2019. Antioxidant, hypoglycemic, and hepatoprotective effect of aqueous and ethyl acetate extract of carob honey in streptozotocin-induced diabetic rats. Veterinary World, 12(12), 1916.
  • 19. FAOSTAT. (2023). Production of locust beans (carobs): top 10 producers. Fao’s Website, 2023. https://www.fao.org/faostat/en/#data/QCL/visualize.
  • 20. Fidan H., Stankov S., Petkova N., Petkova Z., Iliev A., Stoyanova M., Ivanova T., Zhelyazkov N., Ibrahim S., Stoyanova A. & Ercisli S. 2020. Evaluation of chemical composition, antioxidant potential and functional properties of carob (Ceratonia siliqua L.) seeds. Journal of Food Science and Technology, 57(7), 2404–2413.
  • 21. Gioxari A., Amerikanou C., Nestoridi I., Gourgari E., Pratsinis H., Kalogeropoulos N., Andrikopoulos N.K. & Kaliora A.C. 2022. Carob: A sustainable opportunity for metabolic health. Foods, 11(14), 2154.
  • 22. Goulas V., Stylos E., Chatziathanasiadou M.V., Mavromoustakos T. & Tzakos A.G. 2016. Functional components of carob fruit: Linking the chemical and biological space. International journal of molecular sciences, 17(11), 1875.
  • 23. Hamza R.G. & Alsiny M. 2015. Effect of using gamma-irradiated mixture extract of carob and roselle in diabetic rats. International Journal of Pharma and Bio Sciences, 6(1), B951–B960.
  • 24. Hussein W.A., Salem A.A., Fahmy H.A., Mouneir S.M., Soliman A.S., & Abbas M.S. 2022. Effect of carob, doum, and cinnamon powder on blood lipid profile in diabetic rats. Egyptian Journal of Chemistry, 65(9), 317–328.
  • 25. Ikram A., Khalid W., Wajeeha Zafar K., ul Ali A., Afzal M.F., Aziz A., Faiz ul Rasool I., Al-Farga A., Aqlan F. & Koraqi H. 2023. Nutritional, biochemical, and clinical applications of carob: A review. Food Science & Nutrition, 11(7), 3641–3654.
  • 26.Jaisson S. & Gillery P. 2018. Les produits de glycation avancée des protéines. Revue Francophone Des Laboratoires, 2018 (502), 48–55.
  • 27. Karim A.A. & Azlan A. 2012. Fruit pod extracts as a source of nutraceuticals and pharmaceuticals. Molecules, 17(10), 11931–11946.
  • 28. Kavvoura D.A., Stefanakis M.K., Kletsas D., Katerinopoulos H.E., & Pratsinis H. 2023. Biological activities of ceratonia siliqua pod and seed extracts: a comparative analysis of two cretan cultivars. International Journal of Molecular Sciences, 24(15), 12104.
  • 29. Laaraj S., Salmaoui S., Addi M., El-Rhouttais C., Tikent A., Elbouzidi A., Taibi M., Hano C., Noutfia Y. & Elfazazi K. 2023. Carob (Ceratonia siliqua L.) seed constituents: A comprehensive review of composition, chemical profile, and diverse applications. Journal of Food Quality, 2023.
  • 30. López-Sánchez J., Moreno D.A., García-Viguer C., López-Sánchez J., Moreno D.A. & García-Viguer C. 2018. D-pinitol, a highly valuable product from carob pods: Health-promoting effects and metabolic pathways of this natural super-food ingredient and its derivatives. AIMS Agriculture and Food 2018, 3(1), 41–63.
  • 31. Macho-González A., López-Oliva M.E., Merino J.J., García-Fernández R.A., Garcimartín A., Redondo-Castillejo R., Bastida S., Sánchez-Muniz F.J. & Benedí J. 2020. Carob fruit extract-enriched meat improves pancreatic beta-cell dysfunction, hepatic insulin signaling and lipogenesis in late-stage type 2 diabetes mellitus model. The Journal of Nutritional Biochemistry, 84, 108461.
  • 32. Martić N., Zahorec J., Stilinović N., Andrejić-Višnjić B., Pavlić B., Kladar N., Šoronja-Simović D., Šereš Z., Vujčić M., Horvat O. & Rašković A. 2022. Hepatoprotective effect of carob pulp flour (Ceratonia siliqua L.) extract obtained by optimized microwaveassisted extraction. Pharmaceutics, 14(3).
  • 33. Martins F.O. &Azab A. 2022. D-Pinitol – active natural product from carob with notable insulin regulation. Nutrients, 14(7), 1453.
  • 34. Miś A. & Dziki D. 2013. Extensograph curve profile model used for characterising the impact of dietary fibre on wheat dough. Journal of Cereal Science, 57(3), 471–479.
  • 35. Mokhtari M., Behzad M., Esfandiar S. & Tabatabaee S.M. 2011. The effect of hydro – alcoholic seeds extract of Ceratonia siliqua L. on the kidney functional factors and serum electrolytes in diabetic male rats. Yafteh, 13(2), 74–82.
  • 36. Moumou M., Mokhtari I., Milenkovic D., Amrani S., & Harnafi H. 2023. Carob (Ceratonia siliqua L.): A comprehensive review on traditional uses, chemical composition, pharmacological effects and toxicology (2002-2022). Journal of Biologically Active Products from Nature, 13(3), 179–223.
  • 37. Moumou M., Mokhtari I., Tayebi A., Milenkovic D., Amrani S., & Harnafi H. 2023. Immature carob pods extract and its fractions prevent lipid metabolism disorders and lipoprotein-rich plasma oxidation in mice: A phytochemical and pharmacological study. Journal of Ethnopharmacology, 117557.
  • 38. Nasar‐Abbas S.M., E‐Huma Z., Vu T.H., Khan M.K., Esbenshade H. & Jayasena V. 2016. Carob kibble: A bioactive‐rich food ingredient. Comprehensive Reviews in Food Science and Food Safety, 15(1), 63-72.
  • 39. Nasrallah K., Khaled S., El Khatib S. & Krayem M. 2023. Nutritional, biochemical and health properties of Locust beans and its applications in the food industry: a review. Journal of Food Science and Technology, 1–10.
  • 40. Nawrocka A., Miś A. & Szymańska-Chargot M. 2016. Characteristics of relationships between structure of gluten proteins and dough rheology – influence of dietary fibres studied by FT-Raman Spectroscopy. Food Biophysics, 11(1), 81–90.
  • 41. Oziyci H.R., Tetik N., Turhan I., Yatmaz E., Ucgun K., Akgul H., Gubbuk H. & Karhan M. 2014. Mineral composition of pods and seeds of wild and grafted carob (Ceratonia siliqua L.) fruits. Scientia Horticulturae, 167, 149–152.
  • 42. Polat Ş., Hamakhan A., Kafkas E., Com & Ali Md. A. 2023. Determination of sugars and organic acids in diverse carob genotypes using HPLC techniques. International Journal of Agriculture, Environment and Food Sciences, 756–760.
  • 43. Prakash O., Kumar R., Srivastava R., Tripathi P., Mishra S. & Ajeet. 2015. Plants explored with antidiabetic properties: a review. American Journal of Pharmacological Sciences, 3(3), 55–66.
  • 44. Qasem M.A., Noordin M.I., Arya A., Alsalahi A. & Jayash S.N. 2018. Evaluation of the glycemic effect of Ceratonia siliqua pods (Carob) on a streptozotocin-nicotinamide induced diabetic rat model. PeerJ, 2018(5), e4788.
  • 45. Rasheed D.M., El-Kersh D.M., & Farag M.A. 2019. Ceratonia siliqua (Carob-Locust Bean) outgoing and potential trends of phytochemical, economic and medicinal merits. Wild Fruits: Composition, Nutritional Value and Products, 481–498.
  • 46. Rizzo V., Tomaselli F., Gentile A., La Malfa S. & Maccarone E. 2004. Rheological properties and sugar composition of locust bean gum from different carob varieties (Ceratonia siliqua L.). Journal of Agricultural and Food Chemistry, 52(26), 7925–7930.
  • 47. Rodríguez-Solana R., Romano A., Moreno-Rojas J.M., Romano A., Moreno-Rojas J.M. & Ma W. 2021. Carob pulp: A nutritional and functional by-product worldwide spread in the formulation of different food products and beverages. A Review. Processes, 9(7), 1146.
  • 48. Rtibi K., Jabri M.A., Selmi S., Souli A., Sebai H., El-Benna J., Amri M. & Marzouki L. 2015. Carob pods (Ceratonia siliqua L.) inhibit human neutrophils myeloperoxidase and in vitro ROS-scavenging activity. RSC Advances, 5(102), 84207–84215.
  • 49. Rtibi K., Selmi S., Grami D., Amri M., Eto B., El-benna J., Sebai H. & Marzouki L. 2017. Chemical constituents and pharmacological actions of carob pods and leaves (Ceratonia siliqua L.) on the gastrointestinal tract: A review. Biomedicine and Pharmacotherapy Vol. 93, pp. 522–528.
  • 50. Said A.A., Kairy M.H., Shalaby A.M.E. & Ismail H.T. 2017. The effect of carob pods and fig fruits ether extracts against lead induced hematological and biochemical changes in Oreochromis niloticus. Zagazig Veterinary Journal, 45(1), 19–28.
  • 51. Siano F., Mamone G., Vasca E., Puppo M.C. & Picariello G. 2023. Pasta fortified with C-glycosidesrich carob (Ceratonia siliqua L.) seed germ flour: Inhibitory activity against carbohydrate digesting enzymes. Food Research International, 170, 112962.
  • 52. Skalli S., Hassikou R. & Arahou M. 2019. An ethnobotanical survey of medicinal plants used for diabetes treatment in Rabat, Morocco. Heliyon, 5(3).
  • 53. Stavrou I.J., Christou A. & Kapnissi-Christodoulou C.P. 2018. Polyphenols in carobs: A review on their composition, antioxidant capacity and cytotoxic effects, and health impact. Food Chemistry, 269, 355–374.
  • 54. Tetik N., Turhan I., Oziyci H.R. & Karhan M. 2011. Determination of d-pinitol in carob syrup. International Journal of Food Sciences and Nutrition, 62(6), 572–576.
  • 55. Zhu B.J., Zayed M.Z., Zhu H.X., Zhao J. & Li S.P. 2019. Functional polysaccharides of carob fruit: A review. Chinese medicine, 14(1), 40.
Uwagi
Opracowanie rekordu ze środków MNiSW, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2024).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-c757315b-4fe0-446d-aee4-800408e3fbe5
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.