In vitro release studies of poorly water-soluble compounds using the flow-through cell USP4 apparatus

• Autorzy: Bialik-Wąs Katarzyna , Sapuła Paulina

Identyfikatory

DOI

10.24425/cpe.2023.144700

• Konferencja: 24th Polish Conference of Chemical and Process Engineering, 13-16 June 2023, Szczecin, Poland. Guest editor: Prof. Rafał Rakoczy and 8th European Process Intensification Conference, 31.05–2.06.2023, Warsaw, Poland
• Języki publikacji: EN

Abstrakty

EN

Currently, there is a tendency for new forms of carrier-drug systems to appear with prolonged and controlled release. However, in order to design medical or pharmaceutical devices, which have to be characterized by high quality and the assumed parameters in real conditions, it is necessary to analyze this process based on in vitro release (IVR) testing methods. For this purpose, extracorporeal studies are carried out, which enable the determination of the release profiles of active substances using a simulated tissue-like environment. Here, we focused on the release tests of poorly water-soluble compounds (salicylic acid and fluocinolone acetonide) from the dual drug delivery system using the flow-through cell method (USP4). Additionally, bio-hybrid hydrogel matrix containing the system of thermosensitive nanocarrier with salicylic acid and fluocinolone acetonide was subjected to the following investigations: physicochemical (swelling ability, gel fraction), morphological (SEM analysis) and structural using FT-IR spectroscopy. On the basis of results, we can conclude that the USP4 method may be suitable, especially for the release tests of poorly water-soluble components introduced into modern forms of drug administration, such as polymeric matrices, hydrogels, nano- and microcarriers as well as hybrid systems.

Słowa kluczowe

EN

release study; hydrogels; poorly-water soluble compounds; USP4 method

PL

badanie uwalniania; hydrożele; związki słaborozpuszczalne w wodzie; metoda USP4

• Wydawca: Komitet Inżynierii Chemicznej i Procesowej Polskiej Akademii Nauk
• Czasopismo: Chemical and Process Engineering : New Frontiers
• Rocznik: 2023
• Tom: Vol. 44, nr 3
• Strony: art. no. e14
• Opis fizyczny: Bibliogr. 25 poz.

Twórcy

autor

Bialik-Wąs Katarzyna

• Cracow University of Technology, Faculty of Chemical Engineering and Technology, Department of Organic Chemistry and Technology, Warszawska 24, 31-155 Cracow, Poland

• https://orcid.org/0000-0002-1757-9499

autor

Sapuła Paulina

• Cracow University of Technology, Faculty of Chemical Engineering and Technology, Department of Organic Chemistry and Technology, Warszawska 24, 31-155 Cracow, Poland

• https://orcid.org/0000-0003-4508-6234

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr POPUL/SP/0154/2024/02 w ramach programu "Społeczna odpowiedzialność nauki II" - moduł: Popularyzacja nauki (2025)