Tytuł artykułu
Wybrane pełne teksty z tego czasopisma
Identyfikatory
Warianty tytułu
Języki publikacji
Abstrakty
Flavonoids are the most abundant components in Salvia plebeia, with significant pharmacological antioxidant and hepatoprotective properties. Hispidulin and homoplantaginin are the main flavonoid components in S. Plebeia. In this study, we established an ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to determine hispidulin and homoplantaginin in rat plasma samples, which were precipitated using acetonitrile-methanol (9:1, v/v). We used a UPLC HSS T3 (100 mm × 2.1 mm, 1.7 μm diameter) chromatographic column, an acetonitrile-water (containing 0.1% formic acid) mobile phase, and a gradient elution flow rate of 0.4 mL min⁻¹ in an elution time of 4 min. We used electrospray ionization (ESI) detection in positive ion mode, and multiple reaction monitoring mode (MRM) for quantitative analysis: m/z 301 → 286 for hispidulin, m/z 463 → 301 for homoplantaginin, and m/z 465 → 303 for internal standard (IS). In pharmacokinetic studies, 24 rats were orally administered hispidulin and homoplantaginin (5 mg kg⁻¹) and received sublingual intravenous injections (1 mg kg⁻¹) at two different doses, four groups with six rats/group. Differences in hispidulin and homoplantaginin pharmacokinetics in rat plasma were evaluated. The calibration curve showed good linearity in the 0.5–1,000 ng mL⁻¹ range, with r > 0.99. Precision, accuracy, recovery, matrix effects, and stability results all met standard biological sample detection requirements. Our pharmacokinetic studies showed hispidulin bioavailability was much higher than homoplantaginin at 17.8% and 0.1%, respectively.
Czasopismo
Rocznik
Tom
Strony
331--337
Opis fizyczny
Bibliogr. 27 poz., rys., tab., wykr.
Twórcy
autor
- Clinical Laboratory, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, China
autor
- Analytical and Testing Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China
autor
- Clinical Laboratory, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, China
autor
- Analytical and Testing Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China
autor
- Analytical and Testing Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China
autor
- Shanghai Institute of Pharmaceutical Industry Co., Ltd., Shanghai, China
autor
- Analytical and Testing Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China
Bibliografia
- 1. Kim, J. K.; Kim, W. J.; Hyun, J. M.; Lee, J. S.; Kwon, J. G.; Seo, C.; Song, M. J.; Choi, C. W.; Hong, S. S.; Park, K.; Kim, P.; Sung, H.; Lee, J. K.; Choi, Y. Planta Med. 2017, 83, 1335–41.
- 2. Xu, J.; Wang, M.; Sun, X.; Ren, Q.; Cao, X.; Li, S.; Su, G.; Tuerhong, M.; Lee, D.; Ohizumi, Y.; Bartlam, M.; Guo, Y. J. Nat. Prod. 2016, 79, 2924–32.
- 3. Kim, M. H.; Jung, K.; Nam, K. H.; Jang, H. J.; Lee, S. W.; Kim, Y.; Park, C. S.; Lee, T. H.; Park, J. H.; Choi, J. H.; Rho, M. C.; Oh, H. M. Arch. Pharm. Res. 2016, 39, 1671–81.
- 4. Jang, H. J.; Oh, H. M.; Hwang, J. T.; Kim, M. H.; Lee, S.; Jung, K.; Kim, Y. H.; Lee, S. W.; Rho, M. C. Phytochemistry 2016, 130, 335–42.
- 5. Ren, D. B.; Qin, Y. H.; Yun, Y. H.; Lu, H. M.; Chen, X. Q.; Liang, Y. Z. J. Sep. Sci. 2014, 37, 2118–25.
- 6. Chen, L.; Kang, Y. H. J. Agric. Food Chem. 2014, 62, 2190–7.
- 7. Cao, S. Y.; Ke, Z. L.; Xi, L. M. J. Asian Nat. Prod. Res. 2013, 15, 404–7.
- 8. Nhoek, P.; Chae, H. S.; Kim, Y. M.; Pel, P.; Huh, J.; Kim, H. W.; Choi, Y. H.; Lee, K.; Chin, Y. W. J. Nat. Prod. 2021, 84, 220–9.
- 9. Kim, M.; Kim, J. Y.; Yang, H. S.; Choe, J. S.; Hwang, I. G. Antioxidants (Basel) 2021, 10.
- 10. Dai, Y.; Sun, X.; Li, B.; Ma, H.; Wu, P.; Zhang, Y.; Zhu, M.; Li, H. M.; Qin, M.; Wu, C.Z. Molecules 2021, 26.
- 11. Shin, J.; Kim, O. K.; Kim, S.; Bae, D.; Lee, J.; Park, J.; Jun, W. Nutrients 2020, 12.
- 12. Liang, Y. Y.; Wan, X.H.; Niu, F. J.; Xie, S. M.; Guo, H.; Yang, Y. Y.; Guo, L.Y.; Zhou, C.Z. Biomed. Pharmacother. 2020, 121, 109589.
- 13. Jin, X. F.; Lu, Y. H.; Wei, D. Z.; Wang, Z. T. J. Pharm. Biomed. Anal. 2008, 48, 100–4.
- 14. Jang, H. J.; Lee, S. J.; Kim, C. Y.; Hwang, J. T.; Choi, J. H.; Park, J. H.; Lee, S. W.; Rho, M.C. Molecules 2017, 22.
- 15. He, B.; Zhang, B.; Wu, F.; Wang, L.; Shi, X.; Qin, W.; Lin, Y.; Ma, S.; Liang, J. J. Cardiovasc. Pharmacol. 2016, 67, 93–101.
- 16. Ashaq, A.; Maqbool, M. F.; Maryam, A.; Khan, M.; Shakir, H. A.; Irfan, M.; Qazi, J. I.; Li, Y.; Ma, T. Phytother Res. 2021, 35, 771–89.
- 17. Kang, J.; Lee, S.; Kim, N.; Dhakal, H.; Choi, Y. A.; Kwon, T. K. Khang, D.; Kim, S.H. Biomed. Pharmacother. 2021, 137, 111359.
- 18. Cong, Y.; Wu, S.; Han, J.; Chen, J.; Liu, H.; Sun, Q.; Wu, Y.; Fang, Y. J. Pharm. Biomed. Anal. 2016, 129, 405–9.
- 19. Song, W. U.; Shanshan, L. U.; Wang, R.; Cong, Y.; Han, J.; Fang, Y.; Chen, J. Traditional Chin. Drug Res. Clin. Pharmacol. 2015, 26, 210–3.
- 20. Lin, Z.; Lu, X.; Yu, H.; Jiang, H.; Ma, J.; Bao, S. Latin Am. J. Pharm. 2020, 39, 2221–5.
- 21. Yao, Y.; Wang, H.; Ma, J. Latin Am. J. Pharm. 2021, 40, 1727–31.
- 22. Ma, J.; Wang, X. J. Pharm. Biomed. Anal. 2021, 195, 113894.
- 23. Yang, J.; Zeng, G.; Ma, J.; Wang, X.; Zhou, Q. J. Anal. Methods Chem. 2021, 2021, 6640184.
- 24. Chen, H.; Wang, H.; Liu, H.; Xu, X.; Wen, C.; Li, X. Latin Am. J. Pharm. 2019, 38, 2428–33.
- 25. Li, F.; Chen, Y.; Liu, J.; Jin, Y.; Shao, L. Latin Am. J. Pharm. 2019, 38, 2127–30.
- 26. Lee, N. K.; Choi, S. H.; Park, S. H.; Park, E. K.; Kim, D. H. Pharmacology 2004, 71, 174–80.
- 27. Gong, M.; Yu, L.; Chen, Q.; Xie, B.; Lu, W. Chin. Traditional Herbal Drugs 2009, 40, 392–4.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-c5908253-6247-463c-b9e1-d95210bcda78
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.