Multi-way analysis of retention of model compounds in thin-layer chromatography

• Autorzy: Komsta Ł. , Skibiński R. , Gumieniczek A. , Wojnar A.
• Języki publikacji: EN

Abstrakty

EN

The thin-layer chromatographic (TLC) retention of 35 model compounds has been investigated with ten screening mobile phases on six normal-phase and seven reversed-phase adsorbents. The retention factors formed two cubes with dimensions 35 × 10 × 6 and 35 × 10 × 7, respectively, which enabled three-way analysis by PARAFAC. A one-component PARAFAC model was optimum in both cases and two-component models performed worse. The one-component model explained 78.8% of the variance in normal-phase chromatography and 94.2% of the variance in reversed-phase chromatography. These results showed that the major variability of the retention factor ( R F ) can be modelled as the product of three factors related to the substance itself, the mobile phase, and the adsorbent. R F modelling was substantially better than using k or R M (rate mobility) values.

Słowa kluczowe

EN

retention modelling; N-way methods; PARAFAC; Tucker3

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2010
• Tom: Vol. 22, no. 1
• Strony: 27--36
• Opis fizyczny: Bibliogr. 14 poz., rys., tab.

Twórcy

autor

Komsta Ł.

• Medical University of Lublin Chair and Department of Medicinal Chemistry, Faculty of Pharmacy Jaczewskiego 4 20-090 Lublin Poland

autor

Skibiński R.

• Medical University of Lublin Chair and Department of Medicinal Chemistry, Faculty of Pharmacy Jaczewskiego 4 20-090 Lublin Poland

autor

Gumieniczek A.

• Medical University of Lublin Chair and Department of Medicinal Chemistry, Faculty of Pharmacy Jaczewskiego 4 20-090 Lublin Poland

autor

Wojnar A.

• Medical University of Lublin Chair and Department of Medicinal Chemistry, Faculty of Pharmacy Jaczewskiego 4 20-090 Lublin Poland

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