Changes in the mechanical properties of femoral cartilage tissue in advanced osteoarthritis

• Autorzy: Dragan Szymon Ł. , Kuropka Piotr , Kulej Mirosław , Gabryś Piotr , Nikodem Anna

Identyfikatory

DOI

10.37190/ABB-01463-2019-01

• Języki publikacji: EN

Abstrakty

EN

The main goal of this article was the analysis of the changes of mechanical properties, thickness and histology of the cartilage in different regions of the femur head in advanced stage of the osteoarthritis. Methods: The study material consisted of cylindrical specimens (9.7 mm) prepared form proximal epiphysis of the human femur bone after hip arthroplasty. The thickness was determined from the reconstruction of the specimen from microtomography (SkyScan 1172, Bruker®) images. Mechanical properties of the cartilage tissue were identified in static indentation test conducted the use of MTS® Synergie 100 testing machine. Histological study enabled us to determine cartilage total thickness as well as location and orientation of the collagen fibers. Results: Depending on the region of the head, the cartilage tissue thickness was in the range (0.74–2.23 mm). The lowest thickness values were obtained for the R5 region and the lowest for R4. Samples from R1–R4 regions differ by 24%. Measurements of cartilage tissue indentation, determined with the help of Hayes’ formula, showed that the values of mechanical parameters in regions R1, R2, R3 and R5 have similar values (the difference between them is about 5.5%). Region R4, which had the smallest thickness, also had the lowest values of mechanical parameters. Conclusions: Using κ coefficients, proposed by Hayes, enabled us to obtain similar values of mechanical parameters in the regions R1, R2, R3 and R5, despite differences in cartilage tissue thickness. The R4 region, which had the weakest mechanical parameters, was characterized by the strongest reduction of the articular cartilage tissue, which was accompanied by an unformed mass of cartilage residue originating from the abraded surface and bursa fluid.

Słowa kluczowe

EN

cartilage tissue; osteoarthritis; indentation test; histology; mechanical properties

PL

tkanka chrzęstna; histologia; właściwości mechaniczne

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2020
• Tom: Vol. 22, no. 1
• Strony: 143--152
• Opis fizyczny: Bibliogr. 30 poz., rys., wykr.

Twórcy

autor

Dragan Szymon Ł.

• Department of Regenerative and Restoration Medicine in Orthopedics, Department of Orthopaedics and Traumatology, Wrocław Medical University, Wrocław, Poland

autor

Kuropka Piotr

• Division of Histology and Embryology, Wrocław University of Environmental and Life Sciences, Wrocław, Poland

autor

Kulej Mirosław

• Department of Regenerative and Restoration Medicine in Orthopedics, Department of Orthopaedics and Traumatology, Wrocław Medical University, Wrocław, Poland

autor

Gabryś Piotr

• Clinic of Orthopaedics and Traumatology, Wrocław University Hospital, Wrocław, Poland

autor

Nikodem Anna

• Department of Mechanics, Materials and Biomedical Engineering, Faculty of Mechanical Engineering, Wrocław University of Science and Technology, Wrocław, Poland

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).