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Currently, the pharmaceutical industry is one of the most developing and dynamic sectors of the global economy. Existing methods of wastewater treatment do not always allow the complete removal of pharmacological preparations, which leads to the fact that these substances enter water resources and can have a negative impact on ecosystems and human health. Due to the increase in water pollution with pharmacological preparations, there is a need for more in-depth research in this area. Assessment of the level of contamination with pharmacological substances in the wastewater of megacities is an important aspect of environmental protection and public health. The purpose of this research work is to evaluate pharmacological pollutants in the wastewater of megacities. This study is aimed at identifying APIs (active pharmaceutical ingredients) that are most likely to have a negative impact on the environment in Kazakhstan. To analyze the content of Amoxicillin, Clarithromycin, Ofloxacin, Ciprofloxacin, Atenolol, Metoprolol, Propranolol, Paracetamol, Ibuprofen, Diclofenac, Cabramazepine and other medicinal substances, standards of these substances were added to the wastewater sample and analyzed by the HPLC-MS method. As a result of this research work, information was obtained on the current level of contamination with pharmacological substances in the wastewater of megacities and their impact on ecosystems and human health. The results of the study can be used to develop measures to reduce pollution and conserve water resources for future generations.
Słowa kluczowe
Czasopismo
Rocznik
Tom
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359--370
Opis fizyczny
Bibliogr. 35 poz., rys., tab.
Twórcy
autor
- Department of Botany, E.A. Buketov Karaganda University, Karaganda, Kazakhstan
autor
- Environmental Management and Engeneering Department, L.N. Gumilyov Eurasian National University, Astana, Kazakhstan
autor
- Environmental Management and Engeneering Department, L.N. Gumilyov Eurasian National University, Astana, Kazakhstan
- Insitute of Environmental Engineering, Peopl Friendship University of Russia, Moscow 117198, Russia High School of Ecology, Yugra State University, Khanty Mansiysk 628000, Russia
autor
- Department of Ecology, M. Auezov South Kazakhstan State University, Shymkent, Kazakhstan
autor
- Department of Biology and Genomics, L.N. Gumilyov Eurasian National University, Astana, Kazakhstan
autor
- Environmental Management and Engeneering Department, L.N. Gumilyov Eurasian National University, Astana, Kazakhstan
Bibliografia
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- 2. Aubakirova B.N., BeisenovaR., Boxall A. 2017. Prioritisation of pharmaceuticals based on risks to aquatic environments in Kazakhstan, Integrated Environmental Assessment and Management, 13(5), 832–839.
- 3. Aubakirova B.N. 2017. The effect of pharmaceutical ingredients on representatives of aquatic biota, Thesis for the degree of doctor of philosophy. Gumilyov Eurasian national university, Astana, Kazakhstan, 142.
- 4. Beisenova R., Tulegenova S., Tazitdinova R., Kovalenko O., Turlybekova G. 2020. Purification by Ketoconazole Adsorption from Sewage. Systematic Review Pharmacy, 11(6), 550–554.
- 5. Brausch, J.M., Rand, G.M. 2011. A review of personal care products in the aquatic environment: Environmental concentrations and toxicity. Chemosphere, 82(11), 1518–1532.
- 6. Calamari D., Zuccato E., Castiglioni S., Bagnati R., Fanelli R. 2003. Strategic survey of therapeutic drugs in the rivers po and lambro in northern italy. Environ Sci Technol., 37(7), 1241–1248.
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- 8. Cooper E., Siewicki T., Phillips K. 2008. Preliminary risk assessment database and risk ranking of pharmaceuticals in the environment // Sci. Total Environ., 398(1–3), 26–33.
- 9. Deblonde T., Hartemann P. 2013. Environmental impact of medical prescriptions: assessing the risks and hazards of persistence, bioaccumulation and toxicity of pharmaceuticals. Public Health, 4 (127), 312–317.
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- 15. Guo J.H., Sinclair C.J., Selby K., Boxall A.B.A. 2016. Toxicological and ecotoxicological risk-based prioritization of pharmaceuticals in the natural environment. Environ Toxicol and Chem., 35(6), 1550–1559.
- 16. Gurinovich A.D., Zhitenev B.N., Voronovich N.V. 2012. Purification of natural waters from pharmaceuticals by oxidation method. Bulletin of Brest State Technical University, 2, 20–25.
- 17. Halling-Sorensen B., Nors Nielsen S., Lansky P., Ingerslev F., Holten Lutzhoft H., Jorgensen S. 2008. Occurrence, Fate, and Effects of Pharmaceutical Substances in the Environment- a Review // Chemosphere, 32(2), 357–393.
- 18. Halling-Sorensen B. 2000. Algal toxicity of antibacterial agents used in intensive farming. Chemosphere, 40(7), 731–739.
- 19. Hegelund T., Ottosson K., Rådinger M., Tomberg P., Celander M.C. Effects of the antifungal imidazole ketoconazole on Cyp1A and Cyp3A in rainbow trout and killi fish. Environmental Toxicology and Chemistry Environ Toxicol Chem. 2004, 23(5), 1326.
- 20. Kim S., Thiessen P.A., Bolton E.E., Chen J., Fu G., Gindulyte A., Han L., He J., He S., Shoemaker B.A., Wang J., Yu B., Zhang J., Bryant S.H. 2016. PubChem Substance and Compound databases. Nucleic Acids Res., 44(D1), D1202-13.
- 21. Kummerer K. 2001. Emission and Biodegradability of Pharmaceuticals, Contrast Media, Disinfectants and AOX from Hospitals. В: Pharmaceuticals in the Environment. b.m: SpringerVerlag Berlin Heidelberg, 29–41.
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- 23. MHSD. The Ministry of Healthcare and Social Development of the Republic of Kazakhstan. 2015. Health of the Republic of Kazakhstan and the Activities of the Healthcare Organization in 2014. Statistical compilations. [accessed 2023 May 10]. Available from https://pda.mzsr.gov.kz/sites/default/files/sbornik_2014.pdf
- 24. Mutiyar P.K., Mittal A.K. 2013. Occurrences and fate of an antibiotic amoxicillin in extended aeration-based sewage treatment plant in delhi, india: A case study of emerging pollutant. Desalination Water Treat, 51(31–33), 6158–6164.
- 25. OECD. The Organisation for Economic Co-operation and Development. 2009. The Guidance Document for Using the OECD (Q)SAR Application Toolbox to Develop Chemical Categories According to the OECD Guidance on Grouping Chemicals. OECD Series on Testing and Assessment. No. 102. [accessed 2016 Feb 20]. Available from http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?doclanguage=en&cote=env/jm/mono(2009)5
- 26. Office of National Statistics. Population of the Republic of Kazakhstan as of January 1, 2024. Date accessed: February 21, 2024.
- 27. Oguz M., Mihciokur H. 2014. Environmental risk assessment of selected pharmaceuticals in Turkey. Environ Toxicol Phar., 38(1), 79–83.
- 28. Porsbring T., Blanck H., Tjellström H., Backhaus T. Toxicity of the pharmaceutical clotrimazole to marine microalgal communities. Aquatic Toxicology. 2009, 91(3), 203–211.
- 29. Roos V., Gunnarsson L., Fick J., Larsson D.G.J., Ruden C. 2012. Prioritising pharmaceuticals for environmental risk assessment: Towards adequate and feasible first-tier selection // Sci. Total. Environ. 421, 102–110.
- 30. Santos L., Araujo A.N., Fachini A., Pena A., Delerue-Matos C., Montenegro M. 2010. Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment. J Hazard Mater., 175(1–3), 45–95.
- 31. Shi H., Sun Z., Liu Z., Xue Y. Effects of clotrimazole and amiodarone on early development of amphibian (Xenopus tropicalis). Toxicological & Environmental Chemistry, 2012, 94(1), 128–135.
- 32. Sumpter J. 2010. Pharmaceuticals in the Environment: Moving from a Problem to a Solution: in Green and Sustainable Pharmacy. Kummerer K., Hempel M. (Eds.), Berlin: Springer-Verlag Heidelberg, 11–22.
- 33. Beisenova R., Tulegenova S., Tazitdinova R., Orkeyeva A., Beisenbekova Z. 2022. The problem of water resources pollution with active pharmaceutical substances and the possibility of its solving, Journal of Environmental Management and Tourism, 13(5), 1353–1360.
- 34. Wilkinson J.L., Boxall, A.B.A., Kolpin D.W., Teta C. 2022. Pharmaceutical pollution of the world’s rivers, Proceedings of the National Academy of Sciences of the United States of Americathis link is disabled, 119(8). DOI 10.1073/pnas.2113947119.
- 35. Yasojima M., Nakada N., Komori K., Suzuki Y., Tanaka H. 2006. Occurrence of levofloxacin, clarithromycin and azithromycin in wastewater treatment plant in Japan. Water Sci Technol., 53(11), 227–233
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-c43cc6ee-f7ea-49a0-9b90-e340bce11acb