Cyclodextrine vs D-glucose in the solutions of the derivative of 1,4-DHP

• Autorzy: Kaczmarek-Klinowska Milena , Hornowski Tomasz
• Języki publikacji: PL

Abstrakty

EN

Hydrophilic and hydrophobic cyclodextrins (CDs) have found a lot of applications in medicine pharmacology, food processing and cosmetology. They can function as a drug carrier material and parent host molecules, increasing drug biocompatibility, optimizing the efficiency of drug activity, and controlling drug release at the desired level. The effectiveness of CD complexation depends on many factors such as the type and the size of both the CD molecule itself and the guest molecule, pH of the solution, and temperature. In aqueous solution of glucose the aggregation of molecules can occur leading to the formation of CD-like structures. In the paper the possibility of the formation of the inclusion complexes of CD and glucose with Nimodipine was investigated with the aid of ultrasonic spectroscopy. By comparing the efficiency of industrial saccharides and glucose in the formation of the inclusion complexes the cost effectiveness of the use of glucose as a substitute for CD can be determined.

Słowa kluczowe

PL

cyklodekstryny; alfa-D-glukoza; nimodypina; ultradźwięki; kompleksy gospodarz-gość

EN

cyclodextrin; alpha-D-glucose; nimodipine; ultrasounds; host-guest complexes

• Wydawca: Poznan University of Technology. Institute of Applied Mechanics
• Czasopismo: Vibrations in Physical Systems
• Rocznik: 2019
• Tom: Vol. 30, nr 1
• Strony: art. no. 2019110
• Opis fizyczny: Bibliogr. 7 poz., wykr.

Twórcy

autor

Kaczmarek-Klinowska Milena

• Institute of Acoustics, Faculty of Physics, Adam Mickiewicz University, ul. Uniwersytetu Poznańskiego 2, 61-614 Poznań

autor

Hornowski Tomasz

• Institute of Acoustics, Faculty of Physics, Adam Mickiewicz University, ul. Uniwersytetu Poznańskiego 2, 61-614 Poznań

Bibliografia

• 1. J. Szejtli, Utilization of cyclodextrins in industrial products and processes. J. Mater. Chem., 36 (1997) 575 - 587.
• 2. K. Kawakami, A. Fujita, T. Mikami, H. Yoshii, V. Paramita, T. L. Neoh, T. Furuta, Formation of rice flavor powder with α-cyclodextrin by spray drying. Eur. Food Res. Technol., 229 (2009) 239 - 245.
• 3. R. Bhardwaj, R. T. Dorr, J. Blanchard, Approaches to reducing toxicity of parenteral anticancer drug formulations using cyclodextrins. PDA J. Pharm. Sci. Technol., 54 (2000) 233 - 239.
• 4. K. Sygnecka, C. Heine, N. Scherf, M. Fasold, H. Binder, C. Scheller, H. Frank, Nimodipine enhances neurite outgrowth in dopaminergic brain slice co-culture, Int. J. Dev. Neurosci., 40 (2015) 1 - 11.
• 5. Yong-Zhong Du, Jia-Guo Xu, Ling Wang, Hong Yuan, Fu-Qiang Hu, Preparation and characteristics of hydroxypropyl-b-cyclodextrin polymericnanocapsules loading nimodipine, Eur. Polym. J., 45 (2009) 1397 - 1402.
• 6. G. C. Benson, O. Kiyohara, Evaluation of excess isentropic compressibilities and isochoric heat capacities, J. Chem. Thermodynamics, 11 (1979) 1061 - 1064.
• 7. F. Eggers, U. Kaatze, Broadband ultrasonic measurement techniques for liquid, Meas. Sci. Technol., 7 (1996) 1 - 9.

Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).