Fluorescent Polysaccharide-Silica-Based Drug Conjugate Nanocarrier Inhibit Non-small Cell Lung Cancer Proliferation

• Autorzy: Sun Taixu , Ge Dengfeng , Zhang Ying , Zhang Bin

Identyfikatory

DOI

10.2478/pjct-2025-0012

• Języki publikacji: EN

Abstrakty

EN

Non-small cell lung cancer (NSCLC) is a highly prevalent and aggressive type of lung cancer, often associated with a poor prognosis. Cucurbitacin B, a natural tetracyclic triterpene, has demonstrated remarkable anticancer activity. In this study, we engineered a novel drug delivery system, Dex-APDMS@CP1@1@ Cucurbitacin B, which incorporates synthetically derived compound 1 to enhance the therapeutic efficacy of Cucurbitacin B. The system was comprehensively characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and nitrogen adsorption techniques. Results revealed excellent stability, a uniform particle size of approximately 500 nm, and a high drug-loading efficiency of 35.2 ± 2.1 wt%. Additionally, the in vitro drug release study indicated that 88.6 ± 3.5% of Cucurbitacin B was released within 12 hours, demonstrating a rapid release profile. The successful encapsulation of the drug was further confirmed by effective fluorescence quenching. In vitro experiments showed that the Dex-APDMS@CP1@1@Cucurbitacin B system significantly inhibited the proliferation of NSCLC cells, highlighting its great potential for targeted cancer therapy.

Słowa kluczowe

EN

NSCLC; Non-small cell lung cancer; Cucurbitacin B; Fluorescence quenching

• Wydawca: West Pomeranian University of Technology. Publishing House
• Czasopismo: Green Sciences
• Rocznik: 2025
• Tom: Vol. 27, nr 3
• Strony: 1--9
• Opis fizyczny: Bibliogr. 24 poz., rys., tab., wz., wykr.

Twórcy

autor

Sun Taixu

• Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, China

autor

Ge Dengfeng

• Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, China

autor

Zhang Ying

• Department of cardiothoracic surgery, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, China

autor

Zhang Bin

• Department of cardiothoracic surgery, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, China

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