Chromatographic fingerprints and quantitative analysis for the quality evaluation of Bao-Yuan Decoction by ultra-performance liquid chromatography coupled with diode array and evaporative light scattering detection

• Autorzy: Zhang Min , Zhu Zhenling , Wang Mengyue , Hou Jincai , Li Yinqing , Xiaobo Li

Identyfikatory

DOI

10.1556/1326.2020.00858

• Języki publikacji: EN

Abstrakty

EN

Bao-Yuan Decoction (BYD), a widely used traditional Chinese medicine formula, is worth developing into modern dosage forms. To assess the quality of traditional decoction, the commonly used ultra-performance liquid chromatography coupled with diode array and evaporative light scattering detection (UPLC-DAD/ELSD) method was initially applied to develop the analytical methods for the qualitative fingerprints and simultaneous quantitation of multiple marker compounds in BYD. Based on 16 batches of BYD prepared from multiple batches of qualified crude herbs combined randomly, the characteristic fingerprints were generated, with 41 and 19 common peaks detected by DAD and ELSD, respectively. Furthermore, ginsenosides Re, Rg1 and Rb1, calycosin-7-glucoside, calycosin, liquiritin, isoliquiritin apioside, isoliquiritin, glycyrrhizic acid and cinnamic acid were qualified as marker compounds to represent the herbs composing the formula. The characteristic fingerprints and the content ranges of multiple batches of the decoction were obtained, thus providing guidance for the quality control of modern dosage forms. The combination of these qualitative and quantitative methods will be an effective operational measure by which to evaluate and control the quality of BYD from traditional decoction to modern dosage forms.

Słowa kluczowe

EN

Bao-Yuan decoction; BYD; fingerprints; quantitation; quality evaluation

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2022
• Tom: Vol. 34, no. 1
• Strony: 87--99
• Opis fizyczny: Bibliogr. 12 poz., rys., tab.

Twórcy

autor

Zhang Min

• School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China

autor

Zhu Zhenling

• School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China

autor

Wang Mengyue

• School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China

autor

Hou Jincai

• Jing-Jin-Ji Joint Innovation Pharmaceutical (Beijing) Co., Ltd. 100 Balizhuang Road, Beijing 100025, PR China
• Shineway Pharmaceutical Group Ltd., 168 Shiluan Street, Shijiazhuang 051430, PR China

autor

Li Yinqing

• Jing-Jin-Ji Joint Innovation Pharmaceutical (Beijing) Co., Ltd. 100 Balizhuang Road, Beijing 100025, PR China
• Shineway Pharmaceutical Group Ltd., 168 Shiluan Street, Shijiazhuang 051430, PR China

autor

Xiaobo Li

• School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China

• https://orcid.org/0000-0002-7500-9275

Bibliografia

• 1. Mo, Y. Q.; Tang, J.; Kang, S. P.; Wu, S. J.; Li, B. H.; Wang, T. H. Cardiovasc. Dis. J. Integr. Tradit. Chin. West. Med. 2016, 4, 62–3.
• 2. Qin, Q. J. Pract. Tradit. Chin. Intern. Med. 2007, 21, 60–1.
• 3. Wang, X.; Gao, G; Hu, J. J. Hainan Med. Univ. 2012, 18, 235–7.
• 4. Li, Y. Q.; Zhang, C. H.; Wang, J. N. J. Tradit. Chin. Medicin. Lit. 2014, 32, 15–6.
• 5. Ma, X. L; Guo, X. Y.; Song, Y. L.; Qiao, L. R.; Wang, W. G.; Zhao, M. B.; Tu, P. F.; Jiang, Y. Sci. Rep. 2016, 1–16.
• 6. China Pharmacopoeia Committee. Pharmacopoeia of the People’s Republic of China (I); China Medical Science Press: Beijing, 2015, pp. 8–9.
• 7. China Pharmacopoeia Committee. Pharmacopoeia of the People’s Republic of China (I); China Medical Science Press: Beijing, 2015, pp. 302–3.
• 8. China Pharmacopoeia Committee. Pharmacopoeia of the People’s Republic of China (I); China Medical Science Press: Beijing, 2015; pp. 86–7.
• 9. China Pharmacopoeia Committee. Pharmacopoeia of the People’s Republic of China (I); China Medical Science Press: Beijing, 2015, pp. 136–7.
• 10. Yang, J. J.; Zhao, D. Q.; Zhang, W. Y.; Bai, X. Y.; Wang, S. M. Chin. Tradit. Herb. Drugs 2019, 50, 5778–84.
• 11. Zhou, L. J.; Wang, Z. X.; Long, T. T.; Zhou, X.; Bao, Y. X. Immunol. J. 2017, 33, 469–76.
• 12. Fang, J. Strait Pharm. J. 2017, 29, 28–30.

Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).