Development of surface modification methods for ReligaHeart® cardiac support system

• Autorzy: Major R. , Kustosz R. , Trembecka-Wójciga K. , Lackner J. M. , Major B.

Identyfikatory

DOI

DOI: 10.1515/amm-2016-0229

• Języki publikacji: EN

Abstrakty

EN

The work is a review of the methods of the surface modification performed by the authors dedicated for for cardiac support system. It presents the evolution of designing the surface dedicated to direct contact with blood. Initially thin and ultrathin coatings were developed. They were designed as a blood-polymer barrier. The pneumatic heart assist devices are made of a medical grade polyurethane. A major milestone was to create advanced ceramic thin films expressing the flexible effects deposited by physical techniques. Coatings have evolved. Another milestone was the surface reproducing the microenvironment to capture progenitor cells from the bloodstream. Thin coatings were prepared, using methods of ion been, controlled residual stresses were introduced. Wrinkles appeared without cracking. This enabled taking control over the process of cell differentiation. Alternatively, the tissue inspired structure resulted of the coating in the form of extracellular matrix. The outer surface was modified with synthetic materials. This enabled the effective proteins docking to induce cell growth, recreating the luminal side of the blood vessel. Coagulation processes have been slowed down. In addition, it was found pro-angiogenic effect.

Słowa kluczowe

EN

ReligaHeart® cardiac support system; pneumatic heart; blood-polymer barrier; proangiogenic effect

• Wydawca: Institute of Metallurgy and Materials Science of Polish Academy of Sciences ; Committee of Materials Engineering and Metallurgy of Polish Academy of Sciences
• Czasopismo: Archives of Metallurgy and Materials
• Rocznik: 2016
• Tom: Vol. 61, iss. 3
• Strony: 1399--1404
• Opis fizyczny: Bibliogr. 15 poz., rys., wykr.

Twórcy

autor

Major R.

• Institute of Metallurgy and Materials Science, Polish Academy of Sciences, 25 Reymonta str., 30-059 Krakow, Poland

autor

Kustosz R.

• Heart Prosthesis Institute, Artificial Heat Laboratory, Wolnosci 345A, 41-800 Zabrze, Poland

autor

Trembecka-Wójciga K.

• Institute of Metallurgy and Materials Science, Polish Academy of Sciences, 25 Reymonta str., 30-059 Krakow, Poland

autor

Lackner J. M.

• Joanneum Research Forschungsges Mbh. Institute of Surface Technologies and Photonics, Functional Surfaces, Leobner, Austria

autor

Major B.

• Institute of Metallurgy and Materials Science, Polish Academy of Sciences, 25 Reymonta str., 30-059 Krakow, Poland

Bibliografia

• [1] A. Kapis, M. Czak, R. Kustosz, M. Gawlikowski, New extracorporeal cardiac support system ReligaHeart EXT (inPolish), in: R. Kustosz, M. Gonsior, A. Jarosz, Eds. Polish artificial heart, the development of design, qualification, preclinical and clinical tests (in Polish) 2013, Epigraf s. c. (2013).
• [2] X. Z. Shu, K. J. Zhu, W. H. Song, International Journal of Pharmaceutics 212, 19-28. (2001)
• [3] Y. L. Zheng, W. L. Yang, C. C. Wang, J. H. Hu, S. K. Fu, L. Dong, L. L. Wu, X. Z. Shen, European Journal of Pharmaceutics and Biopharmaceutics 67, 621-631 (2007)
• [4] D. Y Zhang, X. Z. Shen, J. Y Wang, L. Dong, Y. L. Zheng, L. L. Wu, World Journal of Gastroenterology 14,3554-3562 (2008).
• [5] J. M. Lackner, Industrially-scaled HybridPLD coating at room temperature. Habilitation Thesis, Polish Academy of Sciences, Institute of Metallurgy and Materials Science, Krakow (Poland), 2005.
• [6] J. M. Lackner, W. Waldhauser, R. Major, L. Major, P. Hartmann, Biomimetics in thin film design - Wrinkling and fracture of pulsed laser deposited films in comparison to human skin. Surface & Coatings Technology 215, 192-198 (2013).
• [7] T. Boudou, T. Crouzier, K. Ren, G. Blin, C. Picart, Multiple functionalities of polyelectrolyte multilayer films: new biomedical applications. Advanced Materials. 22 ,441-67 (2010).
• [8] R. Major, Self-assembling surfaces of blood-contacting materials; Journal of Material Science Materials in Medicine; Springer 24,725-733 (2013).
• [9] O. V. Semenov, A. Malek, A. G. Bittermann, J.Vorôs, A. H. Zisch, Engineered polyelectrolyte multilayer substrates for adhesion, proliferation and differentiation of human mesenchymal stem cells, Tissue Engineering:PartA 15, 2977-2990 (2006).
• [10] M. J. Wissink, M. J. van Luyn, R. Beernink, F. Dijk, A. A. Poot, G. H. Engbers, T. Beugeling, W. G. van Aken, J. Feijen, Endothelial cell seeding on cross linked collagen: effects of cross linking on endothelial cell proliferation and functional parameters. Thrombosis and Haemostasis 84, 325—331 (2000).
• [11] C. P. Vazquez, T. Boudou, V. Dulong, C. Nicolas, C. Picart, K. Glinel. Variation of polyelectrolyte film stiffness by photo-cross-linking: way to control cell adhesion, Langmuir 25, 3556-3563 (2009).
• [12] A. Schneider, A. L. Bolcato-Bellemin, G. Francius, J. Jedrzejwska, P. Schaaf, J. C. Voegel, B. Frisch, C. Picart, Glycated polyelectrolyte multilayer films: differential adhesion of primary versus tumor cells, Biomacromolecules 7, 2882-2889 (2006).
• [13] A. Schneider, G. Francius, R. Obeid, P. Schwinte, B. Frisch, P. Schaaf, J. C. Voegel, B. Senger, C. Picart, Polyelectrolyte multilayers with at unableYoungs modulus: influence of film stiffness on cell adhesion, Langmuir 22, 1193-1200 (2006).
• [14] U. T. Seyfert, V. Biehl, J. Schenk, "In vitro hemocompatibility testing of biomaterials according to the ISO 10993-4". Biomol. Eng. 19. (2-6) 91-96 (2002).
• [15] R. Major, F. Brucken, J.M. Lackner, J. Marczak J., B. Major; Surface treatment of thin-film materials to allow dialogue between endothelial and smooth muscle cells and the effective inhibition of platelet activation; The Royal Society of Chemistry: Advances 4, 9491-9502 (2014).

Uwagi

EN

The main theme of the work concerns the statutory works of the Institute of Metallurgy and Materials Science PAS and basic research and applied research projects. This publication was prepared under the project: "Development of innovative bioactive prosthetic heart valve". Tins project is implemented under the Program for Applied Research in the path A, according to the agreement PBS3/A7/17/2015, funded by the National Centre for Research and Development and by the Project no. 2014/13/B/ST8/04287 "Bio-inspired thin film materials with the controlled contribution of the residual stress in terms of the restoration of stem cells microenvironment" of the Polish National Centre of Science.