Zastosowanie hodowli in vitro komórek ludzkich w badaniach pestycydów

• Autorzy: Jabłońska-Trypuć A. , Wołejko E. , Wydro U. , Butarewicz A.

Warianty tytułu

EN

The application of the human cell culture in the studies of pesticides impact on the human organism

• Języki publikacji: PL

Abstrakty

PL

W celu zapewnienia zasobów żywności dla rosnącej populacji ludzkiej, powszechnie stosowane są środki ochrony roślin (ś.o.r.) zabezpieczające rośliny przed chorobami wirusowymi, bakteryjnymi, grzybowymi i szkodnikami oraz preparaty stymulujące ich wzrost i rozwój, zwane pestycydami. Celem pracy jest przedstawienie przeglądu literatury na temat sposobu działania ich substancji czynnych (s.cz.) oraz wpływu jaki wywierają na organizm człowieka na poziomie komórkowym. Obecnie powszechnie wykorzystywanym modelem badawczym są hodowle in vitro ludzkich linii komórkowych. Odpowiednio dobrane do eksperymentu linie komórkowe pozwalają na badanie absorpcji różnych substancji chemicznych, w tym pestycydów, poprzez nabłonek układu pokarmowego, oddechowego i skórę. Umożliwiają one ocenę wpływu pestycydów na podstawowe parametry stresu oksydacyjnego oraz funkcjonowanie układu hormonalnego na poziomie molekularnym.

EN

In order to provide the food supply for an increasing human population products protecting plants against viral diseases, bacterial, fungal, pests and preparations stimulating their growth and development, known as pesticides, are commonly used. The aim of the paper is to show the way of their actions and the impact they have on the human body at the cellular level. Currently, in vitro cultures of human cell lines are a common model for research in this field. Properly chosen for the experiment cell lines allow for the study of the absorption of various chemicals, including pesticides through the epithelium of the digestive system, respiratory system and skin. They also enable the study of the effects of pesticides on the basic parameters of oxidative stress and the functioning of the endocrine system at the molecular level.

Słowa kluczowe

PL

pestycyd; linia komórkowa; stres oksydacyjny; układ hormonalny

EN

pesticide; cell line; oxidative stress; endocrine system

• Wydawca: Oficyna Wydawnicza Politechniki Białostockiej
• Czasopismo: Budownictwo i Inżynieria Środowiska
• Rocznik: 2017
• Tom: Vol. 8, no. 1
• Strony: 29--40
• Opis fizyczny: Bibliogr. 43 poz., rys., tab.

Twórcy

autor

Jabłońska-Trypuć A.

• Wydział Budownictwa i Inżynierii Środowiska, Politechnika Białostocka, ul. Wiejska 45A, 15-351 Białystok

autor

Wołejko E.

• Wydział Budownictwa i Inżynierii Środowiska, Politechnika Białostocka, ul. Wiejska 45A, 15-351 Białystok

autor

Wydro U.

• Wydział Budownictwa i Inżynierii Środowiska, Politechnika Białostocka, ul. Wiejska 45A, 15-351 Białystok

autor

Butarewicz A.

• Wydział Budownictwa i Inżynierii Środowiska, Politechnika Białostocka, ul. Wiejska 45A, 15-351 Białystok

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