On the spontaneous condensation of profens, with ketoprofen as an example

• Autorzy: Matlengiewicz M , Sajewicz M. , Gontarska M. , Kronenbach D. , Kowalska T.
• Języki publikacji: EN

Abstrakty

EN

In a series of recently published full-length papers and short communications we attempted to gain deeper insight into elementary reactions which might contribute to the non-linear nature of the spontaneous chiral conversion of low-molecular-weight carboxylic acids. Earlier, we succeeded in demonstrating that amino acids and hydroxy acids can undergo spontaneous peptidization and spontaneous esterification (both regarded as condensation), respectively, when dissolved in 70% aqueous ethanol. In this study we provide experimental proof from thin-layer chromatography and 13 C NMR spectroscopy of spontaneous condensation of profens, with ketoprofen as an example. It can be expected that other profen drugs undergo an analogous condensation. In the future, an analogy between the ability of amino acids, hydroxy acids, and profens to undergo spontaneous peptidization or condensation (as reported in our papers), and the ability of selected organosilanols to undergo the spontaneous oscillatory condensation (as reported elsewhere), might prove essential for better understanding of detailed mechanism of the spontaneous oscillatory in-vitro chiral conversion of the selected low-molecular-weight carboxylic acids.

Słowa kluczowe

EN

ketoprofen; abiotic condensation; oscillatory chiral conversion

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2010
• Tom: Vol. 22, no. 1
• Strony: 81--90
• Opis fizyczny: Bibliogr. 17 poz., rys., tab.

Twórcy

autor

Matlengiewicz M

• Silesian University Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland

autor

Sajewicz M.

• Silesian University Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland

autor

Gontarska M.

• Silesian University Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland

autor

Kronenbach D.

• Silesian University Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland

autor

Kowalska T.

• Silesian University Institute of Chemistry 9 Szkolna Street 40-006 Katowice Poland

Bibliografia

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