Biodegradable polylactide and thermoplastic starch blends as drug release device – mass transfer study

• Autorzy: Labus K. , Trusek-Hołownia A. , Semba D. , Ostrowska J. , Tynski P. , Bogusz J.

Identyfikatory

DOI

10.2478/pjct-2018-0011

• Języki publikacji: EN

Abstrakty

EN

Four different compositions of polylactide/thermoplastic starch blends (PLA/TPS blends) for application as drug carriers were examined. Initially, using cyanocobalamin (1.355 kDa) as a model compound, the blend with the highest starch content (wt. 60%) was selected for further research of mass transfer phenomenon. In this case, different concentrations of acetaminophen (0.151 kDa), doxorubicin hydrochloride (0.580 kDa) and cyanocobalamin (1.355 kDa) were used for determination of particular releasing profiles. Besides from the comparative analysis of obtained results, the values of the overall mass transfer coefficient (K) were calculated for each of tested drug molecules. Depending on the size and properties of used compound, determined values of the coefficient range from 10⁻¹¹  to 10⁻¹³  m/s. Based on these outcomes, it could be stated that PLA/TPS blend selected in preliminary research, seems to be preferred material for fabrication of long-term drug delivery systems, which could be successfully applied for example in anti-cancer therapy.

Słowa kluczowe

EN

polylactide/thermoplastic starch (PLA/TPS) blends; permeability; local drug release; overall mass transport coefficient

• Wydawca: West Pomeranian University of Technology. Publishing House
• Czasopismo: Polish Journal of Chemical Technology
• Rocznik: 2018
• Tom: Vol. 20, nr 1
• Strony: 75--80
• Opis fizyczny: Bibliogr. 35 poz., rys., tab.

Twórcy

autor

Labus K.

• Wroclaw University of Science and Technology, Division of Bioprocess and Biomedical Engineering, Faculty of Chemistry, Poland, Norwida 4/6, 50-373 Wrocław, Poland

autor

Trusek-Hołownia A.

autor

Semba D.

• Wroclaw University of Science and Technology, Division of Bioprocess and Biomedical Engineering, Faculty of Chemistry, Poland, Norwida 4/6, 50-373 Wrocław, Poland

autor

Ostrowska J.

• Wroclaw University of Science and Technology, Division of Bioprocess and Biomedical Engineering, Faculty of Chemistry, Poland, Norwida 4/6, 50-373 Wrocław, Poland

autor

Tynski P.

• New Chemical Syntheses Institute, Department of Organic Technologies, Aleja Tysiąclecia Państwa Polskiego 13A, 24-110 Puławy, Poland

autor

Bogusz J.

• New Chemical Syntheses Institute, Department of Organic Technologies, Aleja Tysiąclecia Państwa Polskiego 13A, 24-110 Puławy, Poland

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Uwagi

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).