Combined BNCT and PET for theranostics

Silarski, Michał; Dziedzic-Kocurek, Katarzyna; Szczepanek, Monika

doi:10.1515/bams-2021-0140

Artykuł - szczegóły

Tytuł artykułu

Combined BNCT and PET for theranostics

Autorzy

Silarski Michał , Dziedzic-Kocurek Katarzyna , Szczepanek Monika

Wybrane pełne teksty z tego czasopisma

Identyfikatory

DOI

10.1515/bams-2021-0140

Warianty tytułu

Języki publikacji

Abstrakty

This short review summarizes the issue of boron distribution monitoring in boron neutron capture therapy (BNCT), which remains a serious drawback of this powerful oncological treatment. Here we present the monitoring methods that are presently used with particular emphasis on the positron emission tomography (PET) which has the highest potential to be used for the realtime monitoring of boron biodistribution. We discuss the possibility of using present PET scanners to determine the boron uptake in vivo before the BNCT treatment with the use of p-boronphenylalanine (BPA) labeled with 18F isotope. Several examples of preclinical studies and clinical trials performed with the use of [18F]FBPA are shown. We also discuss shortly the perspectives of using other radiotracers and boron carriers which may signifi- cantly improve the boron imaging with the use of the state-of-the-art Total-Body PET scanners providing a theranostic approach in the BNCT.

Słowa kluczowe

BNCT therapy dose distribution monitoring PET tomography

Wydawca

Uniwersytet Jagielloński - Collegium Medicum
Index Copernicus Sp. z o.o.

Czasopismo

Bio-Algorithms and Med-Systems

Rocznik

2021

Tom

Vol. 17, no. 4

Strony

293--300

Opis fizyczny

Bibliogr. 57 poz., rys.

Twórcy

autor

Silarski Michał

michal.silarski@uj.edu.pl

Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, 30-348 Cracow, Poland
Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Cracow, Poland

autor

Dziedzic-Kocurek Katarzyna

Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Cracow, Poland

autor

Szczepanek Monika

Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Cracow, Poland
Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Cracow, Poland

Bibliografia

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Bibliografia

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