Poly(lactide-co-glycolide) microspheres with good biocompatibility

• Autorzy: An Runze , Tang Wenmin , Zhao Zhanpeng , Liu Wentao , Kan Liang

Identyfikatory

DOI

10.37190/ABB-02359-2023-06

• Języki publikacji: EN

Abstrakty

EN

Curcumin and icariin have multiple pharmacological effects and are widely used in various fields, but their short half-life, poor bioavailability and low water solubility greatly limit their application in clinical medicine. Poly(lactide-co-glycolide) (PLGA) loaded microspheres not only solve these problems, but also have no toxicity in degradation. Methods: To verify whether PLGA drugloaded microspheres have good biocompatibility, the present experiments used the emulsification-solvent evaporation method to prepare PLGA drug-loaded microspheres and successfully performed the loading of curcumin and icariin. Results: The scanning electron microscopy showed that the particle sizes of the PLGA microspheres were 2–15 μm, icariin/PLGA microspheres were 3–22 μm and curcumin/PLGA microspheres were 5–30 μm. Moreover, the surface of the microspheres was smooth and spherical. Furthermore, the drug loading and encapsulation rate were good. In vitro experiments revealed that the prepared PLGA microspheres were safe and nontoxic, and that they could release drugs stably and slowly. Moreover, their proliferation ability was unaffected after inoculation into bone marrow mesenchymal stem cells (BMSCs), and Alcian blue Staining was performed at last, demonstrating their biocompatibility and important applications in tissue engineering.

Słowa kluczowe

EN

curcumin; icariin; PLGA microspheres; BMSCs

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2023
• Tom: Vol. 25, no. 4
• Strony: 111--120
• Opis fizyczny: Bibliogr. 30 poz., rys., tab., wykr.

Twórcy

autor

An Runze

• Department of Family Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, PR China

autor

Tang Wenmin

• Department of Family Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, PR China

autor

Zhao Zhanpeng

• Department of Family Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, PR China

autor

Liu Wentao

• Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, Liaoning, P.R. China

autor

Kan Liang

• Department of Geriatrics, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, PR China

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