Biological screening and assessment of certain substituted monoazo heterocycles containing sulphur and / or nitrogen and their seleno like moieties

• Autorzy: Khalifa M. E. , Gobouri A. A.

Identyfikatory

DOI

10.1515/pjct-2017-0064

• Języki publikacji: EN

Abstrakty

EN

The monoazo substituted five membered heterocycles, along with their seleno like moieties are still of interest in organic chemistry due to their medicinal and valuable applications. In continuation of our interest in the study of heterocyclic azo compounds containing sulphur and / or nitrogen heteroatoms, the synthesis of 5-aryl mono azo-thiazol-2-ylcarbamoyl-thiophene along with their seleno like derivatives of pyridine, pyridazine and quinolone, were accomplished. All the synthesized compounds were in vitro screening of their antioxidant activity, antitumor activity against Ehrlich ascites carcinoma cell EACC cell line and antimicrobial activity against various pathogenic microorganisms, such as Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli and Salmonella typhimurium) and fungi strains of Aspergillus flavus and Candida albicans. The structural–activity relationship was studied based on the obtained data.

Słowa kluczowe

EN

thiophene; antioxidant activities; antitumor agents; pathogenic microorganisms; selenium

• Wydawca: West Pomeranian University of Technology. Publishing House
• Czasopismo: Polish Journal of Chemical Technology
• Rocznik: 2017
• Tom: Vol. 19, nr 4
• Strony: 28--35
• Opis fizyczny: Bibliogr. 23 poz., rys., tab.

Twórcy

autor

Khalifa M. E.

• Taif University, Department of Chemistry, Faculty of Science, Taif 21974, Saudi Arabia
• Higher Institute for Engineering and Technology, Department of Chemical Engineering, New Dameitta, Egypt

autor

Gobouri A. A.

• Taif University, Department of Chemistry, Faculty of Science, Taif 21974, Saudi Arabia

Bibliografia

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Uwagi

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).