Evaluation of a CGC-FID method for qualitative and quantitative analysis of azole antifungal drugs

• Autorzy: Ekiert R. J. , Krzek J. , Czekaj J. S. , Hubicka U.
• Języki publikacji: EN

Abstrakty

EN

This paper presents a new method for identification and quantitative analysis of six azole antifungal drugs — bifonazole, clotrimazole, econazole, fluconazole, ketoconazole, and miconazole — by capillary gas chromatography (CGC) combined with flame ionization detection (FID). The chromatographic separation conditions were established and the method was validated for precision (RSD = 1.49–3.55%), recovery (98.6–101.2%), and linearity within the range under investigation (∼1.0–33.3 ng). The results obtained show the newly developed procedure is suitable for qualitative and quantitative pharmaceutical analysis of the six azoles.

Słowa kluczowe

EN

azole antifungal drugs; pharmaceutical analysis; capillary gas chromatography; flame-ionization detection

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2009
• Tom: Vol. 21, no. 2
• Strony: 273--282
• Opis fizyczny: Bibliogr. 22 poz., rys., tab.

Twórcy

autor

Ekiert R. J.

• Jagiellonian University Department of Inorganic and Analytical Chemistry, Collegium Medicum 9 Medyczna St 30-688 Kraków Poland

autor

Krzek J.

• Jagiellonian University Department of Inorganic and Analytical Chemistry, Collegium Medicum 9 Medyczna St 30-688 Kraków Poland

autor

Czekaj J. S.

• Jagiellonian University Department of Inorganic and Analytical Chemistry, Collegium Medicum 9 Medyczna St 30-688 Kraków Poland

autor

Hubicka U.

• Jagiellonian University Department of Inorganic and Analytical Chemistry, Collegium Medicum 9 Medyczna St 30-688 Kraków Poland

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