Dopamine-modified halloysite as new anticancer drug carrier system

• Autorzy: Tansik Ecem , Kaplan Can Hatice

Identyfikatory

DOI

10.14314/polimery.2025.5.3

Warianty tytułu

PL

Haloizyt modyfikowany dopaminą jako nowy system dostarczania leków przeciwnowotworowych

• Języki publikacji: EN

Abstrakty

EN

A new anticancer drug carrier system based on polydopamine-functionalized halloysite (PDA-HNT) was developed. Hansen solubility parameters were used to select 5-fluorouracil (5-FU) as an anticancer drug. The obtained system was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), and nuclear magnetic resonance (1H NMR, 19F-NMR). It was shown that PDA-HNT may be a promising drug nanocarrier for delivery systems in cancer therapy.

PL

Opracowano nowy system dostarczania leków przeciwnowotworowych oparty na haloizycie funkcjonalizowanym polidopaminą (PDA-HNT). Na podstawie parametrów rozpuszczalności Hansena jako lek przeciwnowotworowy wybrano 5-fluorouracyl (5-FU). Otrzymany system scharakteryzowano za pomocą spektroskopii w podczerwieni z transformacją Fouriera (FT-IR), spektroskopii fotoelektronów rentgenowskich (XPS), analizy termograwimetrycznej (TGA), magnetycznego 1H- rezonansu jądrowego (1H NMR, 19F-NMR). Wykazano, że PDA-HNT może być obiecującym nanonośnikiem w systemach dostarczania leków w terapii nowotworowej.

Słowa kluczowe

EN

halloysite; polydopamine; 5-fluorouracil; drug carrier system; Hansen solubility parameter

PL

haloizyt; polidopamina; 5-fluorouracyl; system dostarczania leków; parametry rozpuszczalności Hansena

• Wydawca: Sieć Badawcza Łukasiewicz – Instytut Chemii Przemysłowej
• Czasopismo: Polimery
• Rocznik: 2025
• Tom: Vol. 70, nr 5
• Strony: 322--330
• Opis fizyczny: Bibliogr. 32 poz., rys., tab., wykr.

Twórcy

autor

Tansik Ecem

• Division of Polymer Chemistry, Department of Chemistry, Faculty of Science, Hacettepe University, 06800 Beytepe Ankara, Türkiye

• https://orcid.org/0009-0003-1180-2535

autor

Kaplan Can Hatice

• Division of Polymer Chemistry, Department of Chemistry, Faculty of Science, Hacettepe University, 06800 Beytepe Ankara, Türkiye

• https://orcid.org/0000-0002-2886-0788

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