Self-assembling micelles obtained from PLLA/PEG and PDLA/PEG block copolymers in aqueous solutions

• Autorzy: Wu X , Li S.
• Języki publikacji: EN

Abstrakty

EN

A series ofpolylactide-poly(ethylene glycol) (PLA- PEG) block copolymers were synthesized by ring-opening polymerization of L- or D-lactide in the presence of mono- or dihydroxyl PEG, using nontoxic zinc lactate as catalyst. Micelles were then prepared by direct dissolution of the obtained copolymers in aqueous medium without heating or using any organic solvents. Aqueous gel permeation chromatography and dynamic light scattering measurements were carried out to characterize the resulting micelles. Generally, mixed micelles containing both PLLA/PEG and PDLA/PEG copolymers appear lager and more compact compared to single ones. However, the size of mixed micelles is smaller than that of single ones which exhibit an anisotropic structure since stereocomplexation disfavors the formation of anisotropic micelles. The copolymer parameters such as structures, molar mass and PEG fraction strongly influence the formation of anisotropic micelles, and thus lead to various micellar sizes.

Słowa kluczowe

EN

polylactide; polyethylene glycol; stereocomplexation; self-assembly; anisotropy

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2012
• Tom: Vol. 15, no. 113
• Strony: 6--8
• Opis fizyczny: Bibliogr. 8 poz., rys., tab., wykr.

Twórcy

autor

Wu X

• Max Mousseron Institute on Biomolecules, UMR CNRS 5247, University Montpellier I, 34060 Montpellier, France

autor

Li S.

• Max Mousseron Institute on Biomolecules, UMR CNRS 5247, University Montpellier I, 34060 Montpellier, France

Bibliografia

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• [8] X. WU, A.E. Ghzaoui, S. Li: Anisotropic self-assembling micelles prepared by the direct dissolution of PLA/PEG block copolymers with a high PEG fraction. Langmuir 27 (2011) 8000-8008.