Development of simple analytical methods of polychlorinated biphenyls in human serum by gas chromatography negative ion chemical ionization quadrupole mass spectrometry

• Autorzy: Eguchi A. , Enomoto T. , Suzuki N. , Okuno M. , Mori C.

Identyfikatory

DOI

10.1556/1326.2017.00029

• Języki publikacji: EN

Abstrakty

EN

In this study, we developed a highly sensitive, robust method for determining 12 congeners of two to ten chlorinated polychlorinated biphenyls (PCBs) in serum samples using gas chromatography (GC)–mass spectrometry (MS) operating in selected ion monitoring mode (SIM: m/z 35) with negative ion chemical ionization (NICI), and the results were compared with those from GC coupled with high-resolution MS (HRMS) with electron impact (EI). The recovery rates of the surrogate PCB congeners were 97.2%–112% (coefficient of variation: 5.3%–8.5%), and the method detection limits for PCBs in each matrix obtained by GC–NICI–quadrupole mass spectrometry (qMS) were 1.9–20 pg g−1 wet wt. The analytical values of the target compounds in the samples analyzed by GC–NICI–qMS and GC–EI–HRMS were comparable (Passing–Bablok regression: R = 0.888–0.967), and the analytical values obtained via GC–NICI–qMS were almost comparable with those of the certified serum samples from National Institute of Standards and Technology (NIST: SRM1957), indicating that GC–NICI–qMS is suitable for the analysis of tetra- to hepta-chlorinated PCBs in serum samples.

Słowa kluczowe

EN

PCBs; GC–MS; negative ion chemical ionization; serum

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2017
• Tom: Vol. 29, no. 4
• Strony: 503--506
• Opis fizyczny: Bibliogr. 24 poz., rys., tab.

Twórcy

autor

Eguchi A.

• Chiba University, Center for Preventive Medical Sciences, Inage-ku Yayoi-cho 1-33, Chiba City 263-0022, Japan

autor

Enomoto T.

• JEOL Ltd., 1156 Nakagami-cho, Akishima, Tokyo 196-0022, Japan

autor

Suzuki N.

• Chiba University, Center for Preventive Medical Sciences, Inage-ku Yayoi-cho 1-33, Chiba City 263-0022, Japan

autor

Okuno M.

• JEOL Ltd., 1156 Nakagami-cho, Akishima, Tokyo 196-0022, Japan

autor

Mori C.

• Chiba University, Center for Preventive Medical Sciences, Inage-ku Yayoi-cho 1-33, Chiba City 263-0022, Japan
• Chiba University, Department of Bioenvironmental Medicine, Graduate School of Medicine, Chuo-ku Inohana 1-8-1, Chiba City 260-8670, Japan

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Uwagi

PL

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).