Application and evaluation of layered silicate–chitosan composites for site specific delivery of diclofenac

• Autorzy: Kevadiya B. D. , Rajkumar S. , Bajaj H. C.

Identyfikatory

DOI

10.1016/j.bbe.2014.08.004

• Języki publikacji: EN

Abstrakty

EN

The present study focuses on the in situ intercalation of anionic drug (diclofenac sodium, DS) and cationic polymer, Chitosan (CS) in montmorillonite (MMT) for drug release applications. The prepared DS/CS-MMT composites were further compounded with alginate (AL) to form beads to modify release response in gastric juice. The DS/CS-MMT composites were characterized by UV spectroscopy, XRD, FT-IR, TGA and DSC. Antibacterial assay of drug loaded composites was investigated and in vitro cell viability assay results point out the drug encapsulated in clay plates are less toxic to the cell than pristine drug. The in vitro release experiments revealed that the DS was released from DS/CS-MMT/AL in a controlled and pH dependent manner.

Słowa kluczowe

EN

layered structures; chitosan; thermal analysis; biomaterials; controlled release

PL

struktura warstwowa; chitozan; analiza termiczna; biomateriał; uwalnianie kontrolowane

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2015
• Tom: Vol. 35, no. 2
• Strony: 120--127
• Opis fizyczny: Bibliogr. 17 poz., rys., wykr.

Twórcy

autor

Kevadiya B. D.

• Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute, Council of Scientific and Industrial Research (CSIR), Gijubhai Badheka Marg, Bhavnagar 364002, Gujarat, India; Institute of Science, Nirma University, Ahmedabad, Gujarat, India

autor

Rajkumar S.

• Institute of Science, Nirma University, Ahmedabad, Gujarat, India

autor

Bajaj H. C.

• Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute, Council of Scientific and Industrial Research (CSIR), Gijubhai Badheka Marg, Bhavnagar 364002, Gujarat, India

Bibliografia

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